DIBAC-GGFG-NH2CH2-Dxd

Name: DIBAC-GGFG-NH2CH2-Dxd
Brand: MedChemExpress
SKU: HY-147363
Rating: 4.5 (0 reviews)

製品番号: HY-147363 純度: 98.57%: Data Sheet SDS COA 取扱説明書
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Technical Support

DIBAC-GGFG-NH2CH2-Dxd (compound LP4), a Camptothecin (HY-16560) derivative, is a linker-payload of protein-agent conjugates. Dxd (HY-13631D) can be used as a payload for the antibody-coupling drug ADC (DS-8201a).DIBAC-GGFG-NH2CH2-Dxd is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

DIBAC-GGFG-NH2CH2-Dxd 構造式

CAS 番号 : 2758875-01-1

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 1861	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 1861	在庫あり	Estimated Time of Arrival: December 31
Solid
1 mg	$350	在庫あり	Estimated Time of Arrival: December 31
5 mg	$950	在庫あり	Estimated Time of Arrival: December 31
10 mg	$1500	在庫あり	Estimated Time of Arrival: December 31
25 mg	$3000	在庫あり	Estimated Time of Arrival: December 31
50 mg	$4800	在庫あり	Estimated Time of Arrival: December 31
100 mg	$7680	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Drug-Linker Conjugates for ADC アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

DIBAC-GGFG-NH2CH2-Dxd (compound LP4), a Camptothecin (HY-16560) derivative, is a linker-payload of protein-agent conjugates^[1]. Dxd (HY-13631D) can be used as a payload for the antibody-coupling drug ADC (DS-8201a).DIBAC-GGFG-NH2CH2-Dxd is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups^[1]^[2].

体外実験

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1128.16

分子式

C₆₁H₅₈FN₉O₁₂

CAS 番号

2758875-01-1

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(NCC(NCC(N[C@@H](CC4=CC=CC=C4)C(NCC(NCOCC(N[C@@H]5C6=C7C(C(N8C7)=CC([C@](O)(C(OC9)=O)CC)=C9C8=O)=NC%10=CC(F)=C(C)C(CC5)=C%106)=O)=O)=O)=O)=O)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (88.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.8864 mL	4.4320 mL	8.8640 mL
5 mM	0.1773 mL	0.8864 mL	1.7728 mL
10 mM	0.0886 mL	0.4432 mL	0.8864 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 98.57%

Select Batch:

データシート (276 KB) SDS (252 KB)

COA (257 KB) HNMR (477 KB) RP-HPLC (264 KB) MS (69 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Amy Han, et al. Camptothecin analogs conjugated to a glutamine residue in a protein, and their use. WO2022015656A1

[2]. Protein-drug conjugates comprising camptothecin analogs and methods of use thereof

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.8864 mL	4.4320 mL	8.8640 mL	22.1600 mL
	5 mM	0.1773 mL	0.8864 mL	1.7728 mL	4.4320 mL
	10 mM	0.0886 mL	0.4432 mL	0.8864 mL	2.2160 mL
	15 mM	0.0591 mL	0.2955 mL	0.5909 mL	1.4773 mL
	20 mM	0.0443 mL	0.2216 mL	0.4432 mL	1.1080 mL
	25 mM	0.0355 mL	0.1773 mL	0.3546 mL	0.8864 mL
	30 mM	0.0295 mL	0.1477 mL	0.2955 mL	0.7387 mL
	40 mM	0.0222 mL	0.1108 mL	0.2216 mL	0.5540 mL
	50 mM	0.0177 mL	0.0886 mL	0.1773 mL	0.4432 mL
	60 mM	0.0148 mL	0.0739 mL	0.1477 mL	0.3693 mL
	80 mM	0.0111 mL	0.0554 mL	0.1108 mL	0.2770 mL