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  5. Didemnin B

Didemnin B is a depsipeptide extracted from the marine tunicate Trididemnin cyanophorum. Didemnin B can be used for the research of cancer.

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Didemnin B

Didemnin B 構造式

CAS 番号 : 77327-05-0

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 1211 在庫あり
Solution
10 mM * 1 mL in DMSO USD 1211 在庫あり
Solid
1 mg $290 在庫あり
5 mg $720 在庫あり
10 mg $990 在庫あり
25 mg $1450 在庫あり
50 mg $1990 在庫あり
100 mg   お問い合わせ  
200 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Didemnin B 関連抗体

Top Publications Citing Use of Products

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

Didemnin B is a depsipeptide extracted from the marine tunicate Trididemnin cyanophorum. Didemnin B can be used for the research of cancer[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
2 nM
Compound: 27
Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 3 days
Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 3 days
[PMID: 33592144]
HT-29 IC50
2 nM
Compound: 27
Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 3 days
Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 3 days
[PMID: 33592144]
P388 IC50
>1 μM
Compound: 27
Inhibition of RNA synthesis in mouse P388 cells measured after 72 hrs
Inhibition of RNA synthesis in mouse P388 cells measured after 72 hrs
[PMID: 33592144]
P388 IC50
0.1 μM
Compound: 27
Inhibition of protein synthesis in mouse P388 cells measured after 72 hrs
Inhibition of protein synthesis in mouse P388 cells measured after 72 hrs
[PMID: 33592144]
P388 IC50
0.4 μM
Compound: 27
Inhibition of DNA synthesis in mouse P388 cells measured after 72 hrs
Inhibition of DNA synthesis in mouse P388 cells measured after 72 hrs
[PMID: 33592144]
P388 IC50
2 nM
Compound: 27
Antiproliferative activity against mouse P388 cells assessed as cell growth inhibition incubated for 3 days
Antiproliferative activity against mouse P388 cells assessed as cell growth inhibition incubated for 3 days
[PMID: 33592144]
SK-MEL-28 IC50
2 nM
Compound: 27
Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 3 days
Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 3 days
[PMID: 33592144]
体外実験

Didemnin B has activity against miirine B16 melanoma, P388 leukemia, and M5076 sarcoma[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Didemnin B 関連抗体
体内実験

Didemnin B is a potent inhibitor of L1210 growth[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1112.35

分子式

C57H89N7O15
CAS 番号
Appearance

Solid

Color

White to off-white

Sequence

{(2S)-2-Hydroxypropanoyl-Pro}-{d-N-Me-Leu}-Thr-{(3S,4R,5S)-4-amino-3-hydroxy-5-methylheptanoyl-(2S,4S)-4-hydroxy-2,5-dimethyl-3-oxohexanoyl}-Leu-Pro-{Me-Tyr(Me)} (Lactone: Thr3-Thr8)
Sequence Shortening

{(2S)-2-Hydroxypropanoyl-Pro}-{d-N-Me-Leu}-T-{(3S,4R,5S)-4-amino-3-hydroxy-5-methylheptanoyl-(2S,4S)-4-hydroxy-2,5-dimethyl-3-oxohexanoyl}-LP-{Me-Tyr(Me)} (Lactone: Thr3-Thr8)
SMILES

O=C([C@@H](NC([C@H](C([C@@H](OC(C[C@@H]1O)=O)C(C)C)=O)C)=O)CC(C)C)N(CCC2)[C@]2([H])C(N([C@H](C(O[C@@H]([C@@H](C(N[C@]1([H])[C@@H](C)CC)=O)NC([C@@H](CC(C)C)N(C)C([C@H](CCC3)N3C([C@@H](O)C)=O)=O)=O)C)=O)CC(C=C4)=CC=C4OC)C)=O
Structure Classification
Initial Source

Carribean sea tunicate
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Sealed storage, away from moisture
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (89.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8990 mL 4.4950 mL 8.9900 mL
5 mM 0.1798 mL 0.8990 mL 1.7980 mL
10 mM 0.0899 mL 0.4495 mL 0.8990 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8990 mL 4.4950 mL 8.9900 mL 22.4749 mL
5 mM 0.1798 mL 0.8990 mL 1.7980 mL 4.4950 mL
10 mM 0.0899 mL 0.4495 mL 0.8990 mL 2.2475 mL
15 mM 0.0599 mL 0.2997 mL 0.5993 mL 1.4983 mL
20 mM 0.0449 mL 0.2247 mL 0.4495 mL 1.1237 mL
25 mM 0.0360 mL 0.1798 mL 0.3596 mL 0.8990 mL
30 mM 0.0300 mL 0.1498 mL 0.2997 mL 0.7492 mL
40 mM 0.0225 mL 0.1124 mL 0.2247 mL 0.5619 mL
50 mM 0.0180 mL 0.0899 mL 0.1798 mL 0.4495 mL
60 mM 0.0150 mL 0.0749 mL 0.1498 mL 0.3746 mL
80 mM 0.0112 mL 0.0562 mL 0.1124 mL 0.2809 mL
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Didemnin B Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Didemnin B77327-05-0OthersmarinetunicateTrididemnincyanophorumcancerInhibitorinhibitorinhibit

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製品名:
Didemnin B
製品番号:
HY-105055
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