Dimephosphon 

Dimephosphon is an anti-inflammatory agent with antihistamine and antiserotonin activities. Dimephosphon helps maintain the conduction function of the spinal cord and reduces the excitability of spinal motor neurons in the area surrounding the lesion. Dimephosphon directly activates lymphatic vessel movement and improves lymphatic circulation. Dimephosphon can be used for the study of inflammatory edema, acute spinal cord injury and lymphatic circulation disorders^[1][2][3].

The antihistamine and antiserotonin activity of Dimephosphon is shown on models of paw edema caused by subplantar administration of mediators and modulators of inflammation^[1].
Dimephosphon (2.5 % Dimephosphon Solution, 1 mL, daily for 10 days) promotes the recovery of spinal cord conduction function, and its mechanism may be related to anti-edema, vascular protection and reduction of neuronal hyperexcitability, in hybrid dogs with spinal cord injury^[2].
Dimephosphon (50 mg/kg, i.p, once dose) enhances lymphatic circulation by directly activating lymphatic vessel contraction (stimulating vessel wall and valve muscle cells) in rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

208.19

C₈H₁₇O₄P

14394-26-4

O=C(CC(C)(P(OC)(OC)=O)C)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ziganshina LE, et al. [Effect of dimephosphon on the inflammatory reaction]. Farmakol Toksikol. 1988 May-Jun;51(3):58-60.  [Content Brief]

  [2]. A M Eremeev, et al. Effect of Dimephosphon on Functional Recovery of Damaged Spinal Cord. Bull Exp Biol Med. 2006 Feb;141(2):181-3.  [Content Brief]

  [3]. R Kh Khafiz'yanova, et al. Lymphotropic Effect of Dimephosphon, Mexidol, and Ketorolac is Realized via Activation of the Lymphangion and Stimulation of Lymph Formation. Bull Exp Biol Med. doi: 10.1007/s10517-007-0152-5.  [Content Brief]