1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Dirithromycin

Dirithromycin (Synonyms: LY237216)

Cat. No.: HY-B0643 Purity: ≥98.0%
Handling Instructions

Dirithromycin (LY237216), a derivative of Erythromycin, is a potent and orally active semi-synthetic macrolide antibiotic. Dirithromycin is active against gram-positive bacteria, Legionella spp., Helicobacter pylori, and Chlamydia trachomatis.

For research use only. We do not sell to patients.

Dirithromycin Chemical Structure

Dirithromycin Chemical Structure

CAS No. : 62013-04-1

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Solution
10 mM * 1 mL in DMSO USD 88 In-stock
Estimated Time of Arrival: December 31
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Solid
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1 g USD 130 In-stock
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5 g USD 516 In-stock
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Description

Dirithromycin (LY237216), a derivative of Erythromycin, is a potent and orally active semi-synthetic macrolide antibiotic. Dirithromycin is active against gram-positive bacteria, Legionella spp., Helicobacter pylori, and Chlamydia trachomatis[1][2].

In Vitro

Dirithromycin possesses an in vitro spectrum of antimicrobial activity which is similar to that of Erythromycin[2].
Dirithromycin exhibits excellent in vitro activity against several strains of Legionella, with MICs of ~1.0 and <0.25 μg/mL at pH=7.1 and 7.4, respectively[2].
Dirithromycin demonstrates potent activity against several strains of Helicobacter pytori, with MICs of <0.5 μg/mL[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Dirithromycin (s.c. for 2 times) is effective against experimental infections caused by S. aureus, S. pyogenes, and S. pneumoniae in mice, with ED50s of 1.0, 0.6, and <0.6 mg/kg[2].
Dirithromycin (p.o. for 2 times) is effective against experimental infections caused by S. aureus, S. pyogenes, and S. pneumoniae in mice, with ED50s of 27, 34, and 23 mg/kg[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

835.07

Formula

C₄₂H₇₈N₂O₁₄

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : ≥ 50 mg/mL (59.88 mM)

DMSO : 33.33 mg/mL (39.91 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1975 mL 5.9875 mL 11.9750 mL
5 mM 0.2395 mL 1.1975 mL 2.3950 mL
10 mM 0.1198 mL 0.5988 mL 1.1975 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.99 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.99 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% EtOH    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.99 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Dirithromycin
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