1. Anti-infection
  2. Bacterial
  3. Dirithromycin

Dirithromycin (Synonyms: LY237216)

Cat. No.: HY-B0643 Purity: >98.0%
Handling Instructions

Dirithromycin(LY 237216) is a macrolide glycopeptide antibiotic by binding to the 50S subunit of the 70S bacterial ribosome to inhibit the translocation of peptides.

For research use only. We do not sell to patients.

Dirithromycin Chemical Structure

Dirithromycin Chemical Structure

CAS No. : 62013-04-1

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10 mM * 1 mL in DMSO USD 88 In-stock
Estimated Time of Arrival: December 31
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5 g USD 516 In-stock
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Description

Dirithromycin(LY 237216) is a macrolide glycopeptide antibiotic by binding to the 50S subunit of the 70S bacterial ribosome to inhibit the translocation of peptides. Target: Antibacterial Dirithromycin is a new macrolide with a spectrum and degree of in vitro antimicrobial activity similar to that of erythromycin. Compared with erythromycin, dirithromycin has a long elimination half-life enabling once-daily administration, and it also achieves a greater cellular:extracellular concentration ratio and higher concentration in some tissues. Multicentre double-blind clinical trials have shown dirithromycin to be similar in efficacy to erythromycin in the treatment of uncomplicated bacterial infections of the respiratory tract and of skin and soft tissues [1]. Dirithromycin offers some attractive pharmacokinetic properties. The long elimination half-life of dirithromycin allows once-daily dosing and higher and more prolonged tissue concentrations than are achievable with erythromycin. The spectrum of activity, adverse effect profile, clinical efficacy, and bacteriologic eradication rate of dirithromycin may be similar to those of erythromycin [2, 3].

Clinical Trial
Molecular Weight

835.07

Formula

C₄₂H₇₈N₂O₁₄

CAS No.

62013-04-1

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : ≥ 50 mg/mL (59.88 mM)

DMSO : 33.33 mg/mL (39.91 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1975 mL 5.9875 mL 11.9750 mL
5 mM 0.2395 mL 1.1975 mL 2.3950 mL
10 mM 0.1198 mL 0.5988 mL 1.1975 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.99 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.99 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% EtOH    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.99 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

DirithromycinLY237216LY 237216LY-237216BacterialInhibitorinhibitorinhibit

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Dirithromycin
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