1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Dirithromycin

Dirithromycin  (Synonyms: LY237216)

Cat. No.: HY-B0643 Purity: ≥98.0%
COA Handling Instructions

Dirithromycin (LY237216), a derivative of Erythromycin, is a potent and orally active semi-synthetic macrolide antibiotic. Dirithromycin is active against gram-positive bacteria, Legionella spp., Helicobacter pylori, and Chlamydia trachomatis.

For research use only. We do not sell to patients.

Dirithromycin Chemical Structure

Dirithromycin Chemical Structure

CAS No. : 62013-04-1

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Solution
10 mM * 1 mL in DMSO USD 88 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
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ready for reconstitution
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Solid
500 mg USD 80 In-stock
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1 g USD 130 In-stock
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5 g USD 516 In-stock
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Based on 1 publication(s) in Google Scholar

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1 Publications Citing Use of MCE Dirithromycin

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Dirithromycin (LY237216), a derivative of Erythromycin, is a potent and orally active semi-synthetic macrolide antibiotic. Dirithromycin is active against gram-positive bacteria, Legionella spp., Helicobacter pylori, and Chlamydia trachomatis[1][2].

IC50 & Target

Macrolide

 

In Vitro

Dirithromycin possesses an in vitro spectrum of antimicrobial activity which is similar to that of Erythromycin[2].
Dirithromycin exhibits excellent in vitro activity against several strains of Legionella, with MICs of ~1.0 and <0.25 μg/mL at pH=7.1 and 7.4, respectively[2].
Dirithromycin demonstrates potent activity against several strains of Helicobacter pytori, with MICs of <0.5 μg/mL[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Dirithromycin (s.c. for 2 times) is effective against experimental infections caused by S. aureus, S. pyogenes, and S. pneumoniae in mice, with ED50s of 1.0, 0.6, and <0.6 mg/kg[2].
Dirithromycin (p.o. for 2 times) is effective against experimental infections caused by S. aureus, S. pyogenes, and S. pneumoniae in mice, with ED50s of 27, 34, and 23 mg/kg[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

835.07

Formula

C42H78N2O14

CAS No.
SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : ≥ 50 mg/mL (59.88 mM)

DMSO : 33.33 mg/mL (39.91 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1975 mL 5.9875 mL 11.9750 mL
5 mM 0.2395 mL 1.1975 mL 2.3950 mL
10 mM 0.1198 mL 0.5988 mL 1.1975 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.99 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.99 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% EtOH    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.99 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Dirithromycin
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HY-B0643
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