2. Cell Cycle/DNA Damage Anti-infection
  3. DNA/RNA Synthesis Bacterial
  4. DNA Gyrase-IN-11

DNA Gyrase-IN-11 (Compound 23Be) is an inhibitor for protein synthesis (IC50 is 0.74 μM) and DNA replication. DNA Gyrase-IN-11 inhibits DNA gyrase, that inhibits E. coli DNA supercoiling with IC50 of 11.9 μM. DNA Gyrase-IN-11 exhibits antibacterial efficacy, that inhibits Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae and Staphylococcus aureus, with MICs of 0.008-0.25 μg/mL.

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DNA Gyrase-IN-11

DNA Gyrase-IN-11 Chemische Struktur

CAS. Nr. : 2497486-58-3

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Beschreibung

DNA Gyrase-IN-11 (Compound 23Be) is an inhibitor for protein synthesis (IC50 is 0.74 μM) and DNA replication. DNA Gyrase-IN-11 inhibits DNA gyrase, that inhibits E. coli DNA supercoiling with IC50 of 11.9 μM. DNA Gyrase-IN-11 exhibits antibacterial efficacy, that inhibits Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae and Staphylococcus aureus, with MICs of 0.008-0.25 μg/mL[1].

Molekulargewicht

1190.36

Formel

C61H84FN7O16
CAS. Nr.
SMILES

O=C(NC)C1=CC(C#CCO/N=C([C@H](C)C[C@](OC)(C)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](OC(CCNCCCCNC3=CC4=C(C(C(C(O)=O)=CN4C5CC5)=O)C=C3F)=O)[C@@H](C)C6=O)/[C@@H]([C@@H]7[C@@](OC(O7)=O)(C)[C@@H](CC)O6)C)=CN=C1
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Room temperature in continental US; may vary elsewhere.
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DNA Gyrase-IN-11 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Keywords:

DNA Gyrase-IN-112497486-58-3DNA/RNA SynthesisBacterialHaemophilus influenzaeE. coliHepG2HEK293TStreptococcus pneumoniaeStreptococcus pyogenesStaphylococcus aureusInhibitorinhibitorinhibit

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