2. Immunology/Inflammation
  3. IFNAR
  4. Emapalumab

Emapalumab  (Synonyms: NI-0501)

Cat. No.: HY-P99191 Pureté: 98.86%
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SDS
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Emapalumab (NI-0501) is a human monoclonal IgG1 antibody that noncompetitively inhibits IFN-γ. Emapalumab binds with high affinity (Kd= 1.4 pM) to both free IFN-γ as well as IFN-γ bound to its receptor. Emapalumab can be used in research of hemophagocytic lymphohistiocytosis (HLH).

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CAS No. : 1709815-23-5

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Emapalumab Related Antibodies

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Description

Emapalumab (NI-0501) is a human monoclonal IgG1 antibody that noncompetitively inhibits IFN-γ. Emapalumab binds with high affinity (Kd= 1.4 pM) to both free IFN-γ as well as IFN-γ bound to its receptor. Emapalumab can be used in research of hemophagocytic lymphohistiocytosis (HLH)[1].

Isotype

Human IgG1 lambda2
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

IFNg
In Vitro

Emapalumab (NI-0501) impairs IFNcR1 and IFNc-Receptor-2 (IFNcR2) interaction induced by IFNc at the cell surface.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Emapalumab Related Antibodies
Essai clinique
Gene ID

3458  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Masse moléculaire

145.22 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Emapalumab]
Livraison

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 lambda2
Biological Activity
  • Immobilized IFN-gamma Protein, Human can bind Emapalumab. The EC50 for this effect is 3.08 ng/mL.
Pureté et documentation

Purity: 98.86%

SDS (251 KB)

COA (232 KB) SDS-PAGE (85 KB) SEC-HPLC (159 KB)

Inhibitory Antibodies User Guide (603 KB)
Références
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Emapalumab Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Emapalumab1709815-23-5NI-0501NI0501NI 0501IFNARInterferon-α/β receptorInterferon-alpha/beta receptorhumanized monoclonal antibodyhemophagocytic lymphohistiocytosisIFNc-Receptor-2Inhibitorinhibitorinhibit

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