Ethyl 7-(diethylamino)-2-oxo-2H-chromene-3-carboxylate

Cat. No.: HY-W087433 Purity: 99.78%: Data Sheet
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Ethyl 7-(diethylamino)-2-oxo-2H-chromene-3-carboxylate is a potent and selective inhibitor of hMAO-B with an IC₅₀ of 45.52 μM.

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Ethyl 7-(diethylamino)-2-oxo-2H-chromene-3-carboxylate 화학구조

CAS No. : 28705-46-6

사이즈	재고	수량

무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
250 mg	해외재고보유	Estimated Time of Arrival: December 31
500 mg	해외재고보유	Estimated Time of Arrival: December 31
1 g	해외재고보유	Estimated Time of Arrival: December 31
5 g	해외재고보유	Estimated Time of Arrival: December 31
10 g	견적 받기
50 g	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

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View All Monoamine Oxidase Isoform Specific Products:

View All Isoforms

MAO-A MAO-B

Biological Activity
순도&문서
References
고객리뷰

제품 설명

Ethyl 7-(diethylamino)-2-oxo-2H-chromene-3-carboxylate is a potent and selective inhibitor of hMAO-B with an IC₅₀ of 45.52 μM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
BTI-TN-5B1-4	IC₅₀	45.52 μM Compound: 32	Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI-TN-5B1-4 cells assessed as production of hydrogen peroxide from p-tyramine after 15 mins by microplate fluorescence assay Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI-TN-5B1-4 cells assessed as production of hydrogen peroxide from p-tyramine after 15 mins by microplate fluorescence assay	[PMID: 21872365]
LOX IMVI	IC₅₀	> 10 μM Compound: 5	Cytotoxicity against human LOXIMVI cells after 96 hrs by Alamar blue method Cytotoxicity against human LOXIMVI cells after 96 hrs by Alamar blue method	[PMID: 18280154]
OVCAR-5	IC₅₀	> 10 μM Compound: 5	Cytotoxicity against human OVCAR5 cells after 96 hrs by Alamar blue method Cytotoxicity against human OVCAR5 cells after 96 hrs by Alamar blue method	[PMID: 18280154]

분자량

289.33

화학식

C₁₆H₁₉NO₄

CAS No.

28705-46-6

Appearance

Solid

Color

Light green to green

SMILES

O=C(C1=CC2=CC=C(N(CC)CC)C=C2OC1=O)OCC

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 50 mg/mL (172.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4563 mL	17.2813 mL	34.5626 mL
5 mM	0.6913 mL	3.4563 mL	6.9125 mL
10 mM	0.3456 mL	1.7281 mL	3.4563 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

순도&문서

Purity: 99.78%

Select Batch:

Data Sheet (268 KB) SDS (393 KB)

COA (247 KB) HNMR (113 KB) RP-HPLC (189 KB)

Handling Instructions (2659 KB)

References

[1]. Secci D, et al. Synthesis and selective human monoamine oxidase inhibition of 3-carbonyl, 3-acyl, and 3-carboxyhydrazido coumarin derivatives. Eur J Med Chem. 2011 Oct;46(10):4846-52. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.4563 mL	17.2813 mL	34.5626 mL	86.4065 mL
	5 mM	0.6913 mL	3.4563 mL	6.9125 mL	17.2813 mL
	10 mM	0.3456 mL	1.7281 mL	3.4563 mL	8.6407 mL
	15 mM	0.2304 mL	1.1521 mL	2.3042 mL	5.7604 mL
	20 mM	0.1728 mL	0.8641 mL	1.7281 mL	4.3203 mL
	25 mM	0.1383 mL	0.6913 mL	1.3825 mL	3.4563 mL
	30 mM	0.1152 mL	0.5760 mL	1.1521 mL	2.8802 mL
	40 mM	0.0864 mL	0.4320 mL	0.8641 mL	2.1602 mL
	50 mM	0.0691 mL	0.3456 mL	0.6913 mL	1.7281 mL
	60 mM	0.0576 mL	0.2880 mL	0.5760 mL	1.4401 mL
	80 mM	0.0432 mL	0.2160 mL	0.4320 mL	1.0801 mL
	100 mM	0.0346 mL	0.1728 mL	0.3456 mL	0.8641 mL