Formamide (deionized) (Synonyms: Methanamide (deionized); Formimidic acid (deionized))

Name: Formamide (deionized)
Brand: MedChemExpress
SKU: HY-Y0842B
Rating: 5.0 (3 reviews)

Cat. No.: HY-Y0842B Purity: 99.95%: Data Sheet
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Formamide deionized (Methanamide deionizde) is an effective DNA denaturant that significantly reduces the stability of DNA in buffer solutions. Formamide deionized can also be used as a decalcifying agent for rat cardiac cells. Additionally, Formamide deionized is widely used as a solvent or chemical raw material for ion compounds, resins, and plasticizers.

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Formamide (deionized) 화학구조

CAS No. : 75-12-7

사이즈	재고	수량
Solvent
100 mL	해외재고보유	Estimated Time of Arrival: December 31
Solvent
500 mL	해외재고보유	Estimated Time of Arrival: December 31
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5L	견적 받기

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고객리뷰

Based on 3 publication(s) in Google Scholar

Other Forms of Formamide (deionized):

Formamide-¹³C In-stock
Formamide-d₃ In-stock
Formamide-¹⁵N In-stock
Formamide In-stock

3 Publications Citing Use of MCE Formamide (deionized)

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

In Vitro

Formamide deionized (15 mol/L, 15 minutes) can induce the loss of T-tubules in rat cardiac myocytes^[4].
Formamide deionized (25 mL, 10 minutes) induces DNA denaturation in apoptotic Inducer (Staurosporine (HY-15141) treated breast cancer MDA-468 cells, leukemia MOLT-4 cells, and drug-resistant subline MOLT-4/R), but has no effect on the DNA of non-apoptotic cells (actively proliferating MDA-468 and MOLT-4 cells)^[5].
Formamide deionized (0.31-0.5 M, 3 hours) inhibits interkinetic nuclear migration and reduces microtubule quantity in chick embryo neuroepithelial cells^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay ^[6]

Cell Line:	Neuroepithelial cells in the chick embryo
Concentration:	0.1-0.5 M
Incubation Time:	3 h
Result:	Only affected mitosis which was blocked in metaphase so that mitotic figures accumulated near the neuro-coele (0.25 M). Totally inhibited interkinetic nuclear migration and affected only slightly the cell asymmetry (0.31 M). Considerably reduced the amount of cytoplasmic microtubules and that the cells became round (0.37 M). Caused all microtubules had disappeared and all cells were spherical (0.5 M).

In Vivo

Formamide deionized (80-160 mg/kg, oral, once daily, 5 days a week, for 2 weeks, 3 months, or 2 years) exhibits carcinogenic activity in male B6C3F1 mice^[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	B6C3F1 mice^[7]
Dosage:	10-160 mg/kg
Administration:	Oral Gavage (p.o.), once daily, 5 days a week for 2 weeks, 3 months, or 2 years
Result:	Resulted in a significant increase in the incidence of liver hemangiosarcoma, particularly in the 40 mg/kg and 80 mg/kg groups.

분자량

45.04

화학식

CH₃NO

CAS No.

75-12-7

Appearance

Liquid (Density: 1.1334 g/cm³)

Color

Colorless to light yellow

SMILES

O=CN

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, sealed storage, away from moisture and light

용액&용해도

In Vitro:

DMSO : ≥ 166.67 mg/mL (3700.49 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.95%

Select Batch:

Data Sheet (273 KB) SDS (418 KB)

COA (244 KB) HNMR (225 KB) GC (172 KB)

Handling Instructions (2659 KB)

References

[1]. Kamineni VK, et al. Layer-by-layer nanoassembly of polyelectrolytes using Formamide deionized as the working medium. Langmuir. 2007;23(14):7423-7. [Content Brief]

[2]. Blake RD, et al. Thermodynamic effects of Formamide deionized on DNA stability. Nucleic Acids Res. 1996 Jun 1;24(11):2095-103. [Content Brief]

[3]. Costanzo G, et al. Formamide deionized as the main building block in the origin of nucleic acids. BMC Evol Biol. 2007 Aug 16;7 Suppl 2(Suppl 2):S1. [Content Brief]

[4]. Brette F, et al. Validation of Formamide deionized as a detubulation agent in isolated rat cardiac cells. Am J Physiol Heart Circ Physiol. 2002 Oct;283(4):H1720-8. [Content Brief]

[5]. Frankfurt OS, Krishan A. Identification of apoptotic cells by Formamide deionized-induced dna denaturation in condensed chromatin. J Histochem Cytochem. 2001 Mar;49(3):369-78. [Content Brief]

[6]. Messier PE.Messier PE. Effects of Formamide deionized on neuroepithelial cells and on interkinetic nuclear migration in the chick embryo. J Embryol Exp Morphol. 1976 Feb;35(1):197-212. [Content Brief]

[7]. National Toxicology Program. Toxicology and carcinogenesis studies of Formamide deionized (Cas No. 75-12-7) in F344/N rats and B6C3F1 mice (gavage studies). Natl Toxicol Program Tech Rep Ser. 2008 Jul;(541):1-192. [Content Brief]

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	22.2025 mL	111.0124 mL	222.0249 mL	555.0622 mL
	5 mM	4.4405 mL	22.2025 mL	44.4050 mL	111.0124 mL
	10 mM	2.2202 mL	11.1012 mL	22.2025 mL	55.5062 mL
	15 mM	1.4802 mL	7.4008 mL	14.8017 mL	37.0041 mL
	20 mM	1.1101 mL	5.5506 mL	11.1012 mL	27.7531 mL
	25 mM	0.8881 mL	4.4405 mL	8.8810 mL	22.2025 mL
	30 mM	0.7401 mL	3.7004 mL	7.4008 mL	18.5021 mL
	40 mM	0.5551 mL	2.7753 mL	5.5506 mL	13.8766 mL
	50 mM	0.4440 mL	2.2202 mL	4.4405 mL	11.1012 mL
	60 mM	0.3700 mL	1.8502 mL	3.7004 mL	9.2510 mL
	80 mM	0.2775 mL	1.3877 mL	2.7753 mL	6.9383 mL
	100 mM	0.2220 mL	1.1101 mL	2.2202 mL	5.5506 mL

Formamide (deionized) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Formamide (deionized)75-12-7Methanamide (deionized)Formimidic acid (deionized)Biochemical Assay ReagentsDenaturing Polyacrylamide GelsNucleic Acid HybridizationInhibitorinhibitorinhibit

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Formamide (deionized) (Synonyms: Methanamide (deionized); Formimidic acid (deionized))

고객리뷰

Other Forms of Formamide (deionized):

Formamide (deionized) Related Antibodies

3 Publications Citing Use of MCE Formamide (deionized)

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity

순도&문서

References

고객리뷰

Formamide (deionized) Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

Formamide (deionized) Related Classifications

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