75-12-7
75-12-7
Chemical Structure
Formamide
Synonym(s): Methanamide; Formimidic acid
- CAS No.: 75-12-7
- Formula:CH3NO
- Molecular Weight:45.04
IUPAC Name: formamide
InChIKey: ZHNUHDYFZUAESO-UHFFFAOYSA-N
SMILES: O=CN
Biological Activity: Formamide is an effective DNA denaturant that significantly reduces the stability of DNA in buffer solutions. Formamide can also be used as a decalcifying agent for rat cardiac cells. Additionally, formamide is widely used as a solvent or chemical raw material for ion compounds, resins, and plasticizers.[1][2][3][4][5][6][7]
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Formamide | 99.90% | Formamide is an effective DNA denaturant that significantly reduces the stability of DNA in buffer solutions. Formamide can also be used as a decalcifying agent for rat cardiac cells. Additionally, formamide is widely used as a solvent or chemical raw material for ion compounds, resins, and plasticizers. | ||||||||||||||||||||
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Formamide (Standard) | ≥98% | Formamide (Standard) is the analytical standard of Formamide. This product is intended for research and analytical applications. Formamide is an effective DNA denaturant that significantly reduces the stability of DNA in buffer solutions. It induces apoptosis by promoting the formation of cyclic nucleotides and the phosphorylation and dephosphorylation processes of nucleotides, making it useful in cancer research. Formamide can also be used as a decalcifying agent for rat cardiac cells. Additionally, formamide is widely used as a solvent or chemical raw material for ion compounds, resins, and plasticizers. | ||||||||||||||||||||
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Formamide (deionized) | 99.95% | Formamide deionized (Methanamide deionizde) is an effective DNA denaturant that significantly reduces the stability of DNA in buffer solutions. Formamide deionized can also be used as a decalcifying agent for rat cardiac cells. Additionally, Formamide deionized is widely used as a solvent or chemical raw material for ion compounds, resins, and plasticizers. | ||||||||||||||||||||
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Formamide-13C | 99.9% | Formamide-13C is the 13C-labeled Formamide (HY-Y0842). Formamide is an effective DNA denaturant that significantly reduces the stability of DNA in buffer solutions. Formamide can also be used as a decalcifying agent for rat cardiac cells. Additionally, formamide is widely used as a solvent or chemical raw material for ion compounds, resins, and plasticizers. | ||||||||||||||||||||
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Formamide-15N | 99.5% | Formamide-15N is the 15N labeled Formamide (HY-Y0842). Formamide is an effective DNA denaturant that significantly reduces the stability of DNA in buffer solutions. Formamide can also be used as a decalcifying agent for rat cardiac cells. Additionally, formamide is widely used as a solvent or chemical raw material for ion compounds, resins, and plasticizers. | ||||||||||||||||||||
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Formamide-d3 | 99.73% | Formamide-d3 is the deuterium labeled Formamide (HY-Y0842). Formamide is an effective DNA denaturant that significantly reduces the stability of DNA in buffer solutions. Formamide can also be used as a decalcifying agent for rat cardiac cells. Additionally, formamide is widely used as a solvent or chemical raw material for ion compounds, resins, and plasticizers. | ||||||||||||||||||||
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References
- [1]. Kamineni VK, et al. Layer-by-layer nanoassembly of polyelectrolytes using formamide as the working medium. Langmuir. 2007;23(14):7423-7. [Content Brief]
- [2]. Blake RD, et al. Thermodynamic effects of formamide on DNA stability. Nucleic Acids Res. 1996 Jun 1;24(11):2095-103. [Content Brief]
- [3]. Costanzo G, et al. Formamide as the main building block in the origin of nucleic acids. BMC Evol Biol. 2007 Aug 16;7 Suppl 2(Suppl 2):S1. [Content Brief]
- [4]. Brette F, et al. Validation of formamide as a detubulation agent in isolated rat cardiac cells. Am J Physiol Heart Circ Physiol. 2002 Oct;283(4):H1720-8. [Content Brief]
- [5]. Frankfurt OS, Krishan A. Identification of apoptotic cells by formamide-induced dna denaturation in condensed chromatin. J Histochem Cytochem. 2001 Mar;49(3):369-78. [Content Brief]
- [6]. Messier PE.Messier PE. Effects of formamide on neuroepithelial cells and on interkinetic nuclear migration in the chick embryo. J Embryol Exp Morphol. 1976 Feb;35(1):197-212. [Content Brief]
- [7]. National Toxicology Program. Toxicology and carcinogenesis studies of formamide (Cas No. 75-12-7) in F344/N rats and B6C3F1 mice (gavage studies). Natl Toxicol Program Tech Rep Ser. 2008 Jul;(541):1-192. [Content Brief]
