2. Apoptosis Cytoskeleton Cell Cycle/DNA Damage
  3. Apoptosis Microtubule/Tubulin
  4. Fosbretabulin

Fosbretabulin  (Synonyms: Combretastatin A4 phosphate)

Cat. No.: HY-14815
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Fosbretabulin (Combretastatin A4 phosphate) is a vascular disruptor with antitumor activity against atypical thyroid carcinoma (ATC) cell lines and xenografts. Fosbretabulin inhibits tumor growth by inhibiting microtubule polymerization, inducing apoptosis, and suppressing angiogenesis in tumors.

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Fosbretabulin

Fosbretabulin 화학구조

CAS No. : 222030-63-9

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Fosbretabulin Related Antibodies

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제품 설명

Fosbretabulin (Combretastatin A4 phosphate) is a vascular disruptor with antitumor activity against atypical thyroid carcinoma (ATC) cell lines and xenografts. Fosbretabulin inhibits tumor growth by inhibiting microtubule polymerization, inducing apoptosis, and suppressing angiogenesis in tumors[1].

Cellular Effect
Cell Line Type Value Description References
A10 EC50
7 nM
Compound: CA4P
Inhibition of microtubule depolymerization in rat A10 cells assessed as reorganization of interphase microtubule network by indirect immunofluorescence technique
Inhibition of microtubule depolymerization in rat A10 cells assessed as reorganization of interphase microtubule network by indirect immunofluorescence technique
[PMID: 20973488]
DU-145 GI50
0.00336 μM
Compound: CA4P
Growth inhibition of human DU145 cells after 48 hrs by SRB assay
Growth inhibition of human DU145 cells after 48 hrs by SRB assay
[PMID: 28217276]
EA.hy 926 IC50
6.4 μM
Compound: CA4P
Antiproliferative activity against human EAhy926 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human EAhy926 cells measured after 48 hrs by MTT assay
[PMID: 27592394]
EA.hy 926 IC50
6.4 μM
Compound: CA4P
Antiproliferative activity against human EAhy926 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Antiproliferative activity against human EAhy926 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 27597243]
EA.hy 926 IC50
6.4 μM
Compound: CA4P
Antiproliferative activity against human EAhy926 cells after 48 hrs by MTT assay
Antiproliferative activity against human EAhy926 cells after 48 hrs by MTT assay
10.1039/C6MD00360E
HCT-116 IC50
0.042 μM
Compound: CA-4P
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32682200]
HeLa IC50
4.7 nM
Compound: CA4P
Antiproliferative activity against human HeLa cells by sulforhodamine B assay
Antiproliferative activity against human HeLa cells by sulforhodamine B assay
[PMID: 20973488]
HeLa IC50
5.7 nM
Compound: CA4P
Antiproliferative activity against human HeLa cells expressing tubulin 3beta by sulforhodamine B assay
Antiproliferative activity against human HeLa cells expressing tubulin 3beta by sulforhodamine B assay
[PMID: 20973488]
MGC-803 IC50
0.02 μM
Compound: CA-4P
Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32682200]
NCI-H460 GI50
0.00282 μM
Compound: CA4P
Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay
Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay
[PMID: 28217276]
PC-3 IC50
0.033 μM
Compound: CA-4P
Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32682200]
SK-OV-3 GI50
0.0019 μM
Compound: CA4P
Growth inhibition of human SKOV3 cells after 48 hrs by SRB assay
Growth inhibition of human SKOV3 cells after 48 hrs by SRB assay
[PMID: 28217276]
SK-OV-3 IC50
4.5 nM
Compound: CA4P
Antiproliferative activity against human SKOV3 cells by sulforhodamine B assay
Antiproliferative activity against human SKOV3 cells by sulforhodamine B assay
[PMID: 20973488]
SK-OV-3 IC50
6.6 nM
Compound: CA4P
Antiproliferative activity against human SKOV3 cells expressing MDR1-6/6 by sulforhodamine B assay
Antiproliferative activity against human SKOV3 cells expressing MDR1-6/6 by sulforhodamine B assay
[PMID: 20973488]
분자량

396.33

화학식

C18H21O8P
CAS No.
SMILES

O=P(O)(O)OC1=C(C=CC(/C=C\C2=CC(OC)=C(C(OC)=C2)OC)=C1)OC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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Fosbretabulin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fosbretabulin222030-63-9Combretastatin A4Combretastatin A 4Combretastatin A-4ApoptosisMicrotubule/TubulinVascular damagemicrotubule polymerizationapoptosisthyroid cancerInhibitorinhibitorinhibit

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상품명:
Fosbretabulin
Cat. No.:
HY-14815
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