222030-63-9
Chemical Structure
Fosbretabulin
Synonym(s): Combretastatin A4 phosphate
- CAS 番号: 222030-63-9
- Formula:C18H21O8P
- Molecular Weight:396.33
IUPAC Name: (Z)-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl dihydrogen phosphate
InChIKey: WDOGQTQEKVLZIJ-WAYWQWQTSA-N
SMILES: O=P(O)(O)OC1=C(C=CC(/C=C\C2=CC(OC)=C(C(OC)=C2)OC)=C1)OC
Biological Activity: Fosbretabulin (Combretastatin A4 phosphate) is a vascular disruptor with antitumor activity against atypical thyroid carcinoma (ATC) cell lines and xenografts. Fosbretabulin inhibits tumor growth by inhibiting microtubule polymerization, inducing apoptosis, and suppressing angiogenesis in tumors[1].
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Fosbretabulin | Fosbretabulin (Combretastatin A4 phosphate) is a vascular disruptor with antitumor activity against atypical thyroid carcinoma (ATC) cell lines and xenografts. Fosbretabulin inhibits tumor growth by inhibiting microtubule polymerization, inducing apoptosis, and suppressing angiogenesis in tumors. | |||||||||||||||||||||
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Keywords
