GDF11 - growth differentiation factor 11 Gene

Also Known as VHO; BMP11; BMP-11

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10220

About GDF11

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:55,743,122-55,757,264 (from NCBI)

This gene has 2 transcripts (splice variants), 120 orthologues, 31 paralogues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 8.1), endometrium (RPKM 6.4) and 24 other tissues.

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and Other organ systems, and may regulate aging. [provided by RefSeq, Aug 2016]

GDF11 Products (1)

mRNA	Protein	Name
NM_005811.5	NP_005802.1	growth/differentiation factor 11 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18596030	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in activin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	28257634	GOA
involved in positive regulation of SMAD protein signal transduction	IMP IMP: Inferred from mutant phenotype	28257634	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of protein-containing complex	IDA IDA: Inferred from direct assay	24019467	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GDF11 Protein Structure

TGFb_propeptide

TGF_beta

0
100
200
300
407 a.a.

Protein Preferred Names	Protein Names
growth/differentiation factor 11	GDF-11

GDF11 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GDF11	O95390	ACVR2B	Homo sapiens	Q13705	SPR	21054789

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GDF11 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700020AF	Animal-Free GDF-11/BMP-11 Protein, Human (His)	O95390 (N299-S407)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70222Y	GDF-11/BMP-11 Protein, Human (HEK293, solution)	O95390 (N299-S407)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Vertebral Hypersegmentation And Orofacial Anomalies	VHO
Orofacial Clefting Syndrome	Orofacial Clefting
Orofacial Cleft	Cleft, Orofacial
Aging
Cleft Lip With Or Without Cleft Palate	Tessier Cleft Number 1,2
Myostatin-Related Muscle Hypertrophy	Mslhp Muscle Hypertrophy Syndrome
Sacral Defect With Anterior Meningocele	Caudal Regression Syndrome Caudal Regression Sequence Sacral Agenesis Caudal Dysgenesis Syndrome SDAM Caudal Dysplasia Sequence Caudal Dysplasia Sacral Agenesis Syndrome Sacral Regression Syndrome Sacral Defect And Anterior Sacral Meningocele Rudd Klimek Syndrome Sirenomelia
Renal Hypodysplasia/Aplasia 1	Renal Agenesis Renal Adysplasia Renal Aplasia RHDA1 Hereditary Renal Aplasia Hra Hereditary Urogenital Adysplasia Hypodysplasia/Aplasia, Renal, Type 1 Congenital Absence Of Kidneys Syndrome Congenital Absence Of Kidney Aplastic Kidney
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Cleft Palate, Isolated	Cleft Palate Isolated Cleft Palate CPI Cp Palatoschisis Cleft Palate Isolated Uranostaphyloschisis Congenital Fissure Of Palate Cleft Of Secondary Palate

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99720	Luspatercept	Inhibitor	98.92%	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99590A	Sotatercept (mIgG2a)	Inhibitor	99.93%	Unkown

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05351	GDF11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18279	Gdf11 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24757	Gdf11 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GDF11	VGNC	VGNC:62502
Bos taurus	GDF11	VGNC	VGNC:29300
Mus musculus	GDF11	MGD	MGI:1338027
Rattus norvegicus	GDF11	RGD	RGD:2673
Canis familiaris	GDF11	VGNC	VGNC:41159
Macaca mulatta	GDF11	VGNC	VGNC:82150
Others	GDF11	NCBI