CETN2 - centrin 2 Gene

Also Known as CALT; CEN2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1069

About CETN2

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:152,826,994-152,830,757 (from NCBI)

This gene has 2 transcripts (splice variants), 299 orthologues and 20 paralogues. Ubiquitous expression in thyroid (RPKM 47.2), endometrium (RPKM 42.4) and 25 other tissues.

Summary

Caltractin belongs to a family of calcium-binding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggested that caltractin plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome. [provided by RefSeq, Jul 2008]

CETN2 Products (1)

mRNA	Protein	Name
NM_004344.3	NP_004335.1	centrin-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16760425	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in centriole replication	IMP IMP: Inferred from mutant phenotype	12176356	GOA
involved in nucleotide-excision repair	IDA IDA: Inferred from direct assay	15964821	GOA
involved in regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	16760425	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of XPC complex	IDA IDA: Inferred from direct assay	11279143	GOA
located in centriole	IDA IDA: Inferred from direct assay	12176356	GOA
located in centrosome	IDA IDA: Inferred from direct assay	16760425	GOA
part of nuclear pore nuclear basket	IDA IDA: Inferred from direct assay	23591820	GOA
part of transcription export complex 2	IDA IDA: Inferred from direct assay	23591820	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CETN2 Protein Structure

EF-hand_7

EF-hand_8

0
100
172 a.a.

Protein Preferred Names	Protein Names
centrin-2	caltractin (20kD calcium-binding protein)

CETN2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CETN2	P41208	PNMA5	Homo sapiens	Q96PV4	Validated Y2H	25416956
Intra	CETN2	P41208	PNMA5	Homo sapiens	Q96PV4	Y2H Array	25416956
Intra	CETN2	P41208	SGSM1	Homo sapiens	Q2NKQ1-4	Y2H Array	32296183
Intra	CETN2	P41208	SGSM1	Homo sapiens	Q2NKQ1-4	Validated Y2H	32296183
Intra	CETN2	P41208	SGSM1	Homo sapiens	Q2NKQ1-4	Y2H Prey Pooling	25416956
Intra	CETN2	P41208	SGSM1	Homo sapiens	Q2NKQ1-4	Y2H Prey Pooling	32296183
Intra	CETN2	P41208	POC5	Homo sapiens	Q8NA72-3	Y2H Prey Pooling	32296183
Intra	CETN2	P41208	POC5	Homo sapiens	Q8NA72-3	Validated Y2H	32296183
Intra	CETN2	P41208	POC5	Homo sapiens	Q8NA72-3	Y2H Array	32296183
Intra	CETN2	P41208	CCP110	Homo sapiens	O43303	Anti Bait CoIP	16760425
Intra	CETN2	P41208	PKN2	Homo sapiens	Q16513	BioID	26638075
Intra	CETN2	P41208	PKN2	Homo sapiens	Q16513	Anti Tag CoIP	35271311
Intra	CETN2	P41208	POC5	Homo sapiens	Q8NA72	Y2H Array	25416956
Intra	CETN2	P41208	POC5	Homo sapiens	Q8NA72	BioID	26638075
Intra	CETN2	P41208	POC5	Homo sapiens	Q8NA72	Y2H Prey Pooling	25416956
Intra	CETN2	P41208	POC5	Homo sapiens	Q8NA72	Anti Tag CoIP	35271311
Intra	CETN2	P41208	POC5	Homo sapiens	Q8NA72	Y2H Array	29892012
Intra	CETN2	P41208	POC5	Homo sapiens	Q8NA72	Y2H Array	31515488
Intra	CETN2	P41208	XPC	Homo sapiens	Q01831	Anti Tag CoIP	35271311
Intra	CETN2	P41208	XPC	Homo sapiens	Q01831	BioID	26638075
Intra	CETN2	P41208	XPC	Homo sapiens	Q01831	Chromatography	21962512
Intra	CETN2	P41208	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	CETN2	P41208	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	CETN2	P41208	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	CETN2	P41208	SFI1	Homo sapiens	A8K8P3	CD	16956364
Intra	CETN2	P41208	SFI1	Homo sapiens	A8K8P3	ITC	16956364
Intra	CETN2	P41208	SFI1	Homo sapiens	A8K8P3	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CETN2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75351	Centrin-2 Protein, Human (His)	P41208 (A2-Y172)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P75352	Centrin-2 Protein, Human (HEK293, His)	P41208 (M1-Y172)	≥ 95%, as determined by reducing SDS-PAGE.

CETN2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811228	Centrin-2 Antibody	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis Xp De Sanctis-Cacchione Syndrome Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum
Xeroderma Pigmentosum, Complementation Group C	Xeroderma Pigmentosum, Group C XPC Xpcc Xeroderma Pigmentosum Iii Xp3 Xeroderma Pigmentosum Group C Xp Group C Xp, Group C Xeroderma Pigmentosum, Type 3 Xeroderma Pigmentosum Complementation Group C XP-C
Female-Restricted Syndromic X-Linked Intellectual Disability 99	X-Linked Female Restricted Facial Dysmorphism-Short Stature-Choanal Atresia-Intellectual Disability Intellectual Disability, X-Linked 99, Syndromic, Female-Restricted Female-Restricted Syndromic X-Linked Mental Retardation 99 Mrxs99f X-Linked Facial Dysmorphism-Short Stature-Choanal Atresia-Intellectual Disability Syndrome Limited To Females
Xeroderma Pigmentosum, Complementation Group G	Xeroderma Pigmentosum, Group G Xeroderma Pigmentosum Vii Xp7 XPG Xeroderma Pigmentosum Group G Xp Group G Xp, Group G Xpgc Xeroderma Pigmentosum, Group G/Cockayne Syndrome Xeroderma Pigmentosum, Type 7 Xeroderma Pigmentosum Complementation Group G XP-G Xp-G/Cs Xeroderma Pigmentosum Group G/Cockayne Syndrome
Uv-Sensitive Syndrome	Uvss Uv Sensitive Syndrome Ultraviolet Sensitive Syndrome
Trichothiodystrophy 3, Photosensitive	TTD3 Trichothiodystrophy, Complementation Group A Ttda Photosensitive Trichothiodystrophy 3 Trichothiodystrophy Complementation Group A
Cerebrooculofacioskeletal Syndrome	Cerebro-Oculo-Facio-Skeletal Syndrome Cofs Syndrome Pena-Shokeir Syndrome Type 2 Pena Shokeir Syndrome Type 2
Cockayne Syndrome A	Cockayne Syndrome Type 1 Cockayne Syndrome, Type A Cockayne Syndrome Type I CSA Cockayne Syndrome Classic Form Cockayne Syndrome Classical Cockayne Syndrome Type A Ckn1
Trichothiodystrophy	Ttd Amish Brittle Hair Syndrome Bids Syndrome Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome Ibids Pibids Trichothiodystrophy Syndromes
Joubert Syndrome 1	Joubert Syndrome Jbts Cerebellooculorenal Syndrome 1 JBTS1 Joubert-Boltshauser Syndrome Cerebelloparenchymal Disorder Iv Cpd4 Cors1 Joubert Syndrome And Related Disorders Jsrd Familial Aplasia Of The Vermis Joubert Syndrome Related Disorders Js Cerebellar Vermis Agenesis Cerebelloparenchymal Disorder 4 Agenesis Of Cerebellar Vermis Cerebello-Oculo-Renal Syndrome Cors Joubert-Bolthauser Syndrome Cpd Iv Classic Joubert Syndrome Joubert Syndrome Type A Pure Joubert Syndrome Cerebello-Oculo-Renal Syndrome 1 Joubert Syndrome-1 Joubert Syndrome, Type 1 Joubert'S Syndrome
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02547	CETN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19664	Cetn2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26157	Cetn2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CETN2	VGNC	VGNC:106438
Rattus norvegicus	CETN2	RGD	RGD:620247
Felis catus	CETN2	VGNC	VGNC:60800
Bos taurus	CETN2	VGNC	VGNC:27234
Mus musculus	CETN2	MGD	MGI:1347085
Others	CETN2	NCBI