SFI1 - SFI1 centrin binding protein Gene

Also Known as PISD; hSfi1p; PPP1R139

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9814

About SFI1

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:31,496,139-31,618,588 (from NCBI)

This gene has 29 transcripts (splice variants), 154 orthologues and 1 paralogue. Broad expression in lymph node (RPKM 6.7), spleen (RPKM 6.6) and 25 other tissues.

Summary

Enables Phosphatase binding activity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

SFI1 Products (5)

mRNA Protein Name
NM_001007467.3 NP_001007468.1 protein SFI1 homolog isoform a
NM_001258325.1 NP_001245254.1 protein SFI1 homolog isoform c
NM_001258326.2 NP_001245255.1 protein SFI1 homolog isoform d
NM_001258327.2 NP_001245256.1 protein SFI1 homolog isoform e
NM_014775.4 NP_055590.2 protein SFI1 homolog isoform b

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables phosphatase binding IDA
IDA: Inferred from direct assay
19389623 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16956364 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein SFI1 homolog

  • Sfi1 homolog, spindle assembly associated

SFI1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SFI1 A8K8P3 CETN2 Homo sapiens P41208
Fluorescence Spectr
16956364
Intra
SFI1 A8K8P3 CETN2 Homo sapiens P41208
NMR
16956364
Intra
SFI1 A8K8P3 PPP1CA Homo sapiens P62136
Far-WB
19389623
Intra
SFI1 A8K8P3 PPP1CA Homo sapiens P62136
Pull Down
19389623
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Female-Restricted Syndromic X-Linked Intellectual Disability 99

  • X-Linked Female Restricted Facial Dysmorphism-Short Stature-Choanal Atresia-Intellectual Disability

  • Intellectual Disability, X-Linked 99, Syndromic, Female-Restricted

  • Female-Restricted Syndromic X-Linked Mental Retardation 99

  • Mrxs99f

  • X-Linked Facial Dysmorphism-Short Stature-Choanal Atresia-Intellectual Disability Syndrome Limited To Females
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Primary Autosomal Recessive Microcephaly

  • Autosomal Recessive Primary Microcephaly

  • Mcph

  • True Microcephaly

  • Microcephalia Vera

  • Microcephaly Vera

  • Microcephaly Primary Hereditary

  • Microcephaly, Primary, Autosomal Recessive

  • Primary Microcephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12766 SFI1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SFI1 RGD RGD:1560636
Bos taurus SFI1 VGNC VGNC:34514
Canis familiaris SFI1 VGNC VGNC:46075
Felis catus SFI1 VGNC VGNC:65060
Macaca mulatta SFI1 VGNC VGNC:77328
Mus musculus SFI1 MGD MGI:1926137
Others SFI1 NCBI