CCP110 - centriolar coiled-coil protein 110 Gene

Also Known as CP110; Cep110

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9738

About CCP110

Cytogenetic location: 16p12.3 Genomic coordinates (GRCh38): 16:19,523,942-19,553,408 (from NCBI)

This gene has 12 transcripts (splice variants) and 204 orthologues. Broad expression in testis (RPKM 21.6), brain (RPKM 10.5) and 22 other tissues.

Summary

Involved in centriole replication; negative regulation of cilium assembly; and regulation of cytokinesis. Located in centriole and centrosome. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

CCP110 Products (8)

mRNA	Protein	Name
NM_001199022.3	NP_001185951.2	centriolar coiled-coil protein of 110 kDa isoform 1
NM_001323569.2	NP_001310498.1	centriolar coiled-coil protein of 110 kDa isoform 1
NM_001323570.2	NP_001310499.1	centriolar coiled-coil protein of 110 kDa isoform 2
NM_001323571.2	NP_001310500.1	centriolar coiled-coil protein of 110 kDa isoform 2
NM_001323572.2	NP_001310501.1	centriolar coiled-coil protein of 110 kDa isoform 2
NM_001323576.2	NP_001310505.1	centriolar coiled-coil protein of 110 kDa isoform 3
NM_001323577.2	NP_001310506.1	centriolar coiled-coil protein of 110 kDa isoform 3
NM_014711.6	NP_055526.4	centriolar coiled-coil protein of 110 kDa isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12361598	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in centriole replication	IMP IMP: Inferred from mutant phenotype	16244668	GOA
involved in centrosome duplication	IDA IDA: Inferred from direct assay	20596027	GOA
involved in centrosome duplication	IMP IMP: Inferred from mutant phenotype	12361598	GOA
involved in negative regulation of cilium assembly	IMP IMP: Inferred from mutant phenotype	17719545	GOA
involved in regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	16760425	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in centriole	IDA IDA: Inferred from direct assay	17681131	GOA
located in centrosome	IDA IDA: Inferred from direct assay	12361598	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	24421332	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
centriolar coiled-coil protein of 110 kDa	centriolar coiled-coil protein 110kDa

CCP110 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CCP110	O43303	NEURL4	Homo sapiens	Q96JN8	IF	22441691
Intra	CCP110	O43303	NEURL4	Homo sapiens	Q96JN8	Anti Bait CoIP	22441691
Intra	CCP110	O43303	NEURL4	Homo sapiens	Q96JN8	Anti Tag CoIP	22441691
Intra	CCP110	O43303	KIAA0586	Homo sapiens	Q9BVV6	Anti Bait CoIP	24421332
Intra	CCP110	O43303	CCNF	Homo sapiens	P41002	Anti Bait CoIP	22441691
Intra	CCP110	O43303	CCNF	Homo sapiens	P41002	Anti Tag CoIP	20596027
Intra	CCP110	O43303	CEP97	Homo sapiens	Q8IW35	Anti Bait CoIP	35709258
Intra	CCP110	O43303	CEP97	Homo sapiens	Q8IW35	Anti Bait CoIP	21620453
Intra	CCP110	O43303	CEP97	Homo sapiens	Q8IW35	Anti Bait CoIP	24421332
Intra	CCP110	O43303	CEP97	Homo sapiens	Q8IW35	Anti Bait CoIP	18694559
Intra	CCP110	O43303	CEP97	Homo sapiens	Q8IW35	BioID	26638075
Intra	CCP110	O43303	CEP97	Homo sapiens	Q8IW35	Anti Bait CoIP	22441691
Intra	CCP110	O43303	CEP97	Homo sapiens	Q8IW35	Anti Bait CoIP	17719545
Intra	CCP110	O43303	CEP97	Homo sapiens	Q8IW35	Anti Tag CoIP	17719545
Intra	CCP110	O43303	CEP97	Homo sapiens	Q8IW35	Anti Tag CoIP	18694559
Intra	CCP110	O43303	CETN2	Homo sapiens	P41208	Anti Bait CoIP	16760425
Intra	CCP110	O43303	CETN2	Homo sapiens	P41208	Anti Bait CoIP	35709258
Intra	CCP110	O43303	CETN2	Homo sapiens	P41208	Pull Down	16760425
Intra	CCP110	O43303	CEP290	Homo sapiens	O15078	IF	18694559
Intra	CCP110	O43303	CEP290	Homo sapiens	O15078	Anti Bait CoIP	22441691
Intra	CCP110	O43303	CEP290	Homo sapiens	O15078	Anti Bait CoIP	24421332
Intra	CCP110	O43303	CEP290	Homo sapiens	O15078	Y2H	18694559
Intra	CCP110	O43303	CEP290	Homo sapiens	O15078	Anti Bait CoIP	18694559
Intra	CCP110	O43303	CEP290	Homo sapiens	O15078	GMS	18694559
Intra	CCP110	O43303	CEP290	Homo sapiens	O15078	Anti Tag CoIP	18694559
Intra	CCP110	O43303	NUP50	Homo sapiens	Q9UKX7	Anti Bait CoIP	35709258
Intra	CCP110	O43303	KIF24	Homo sapiens	Q5T7B8	Anti Bait CoIP	35709258
Intra	CCP110	O43303	KIF24	Homo sapiens	Q5T7B8	Anti Bait CoIP	21620453

Cross: Cross-species interaction Intra: Intraspecies interaction

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Spinocerebellar Ataxia 11	Spinocerebellar Ataxia Type 11 SCA11 Spinocerebellar Ataxia-11 Ataxia, Spinocerebellar, Type 11
Meckel Syndrome, Type 1	Meckel-Gruber Syndrome Meckel Syndrome Dysencephalia Splanchnocystica Meckel Syndrome 1 MKS1 Mks Gruber Syndrome Meckel-Gruber Syndrome, Type 1 Mes Dysencephalia Splachnocystica Meckel Gruber Syndrome Meckel Syndrome Type 1
Orofaciodigital Syndrome I	OFD1 Orofaciodigital Syndrome 1 Oral-Facial-Digital Syndrome, Type I Oral-Facial-Digital Syndrome 1 Ofds I Papillon-Leage And Psaume Syndrome Papillon-Leage-Psaume Syndrome Oral-Facial-Digital Syndrome Type 1 Orofaciodigital Syndrome Type 1 Orofaciodigital Syndromes Orofaciodigital Syndrome Type I Oral-Facial-Digital Syndrome Type I Ofd Syndrome 1 Ofds 1 Oral Facial Digital Syndrome 1 Oral Facial Digital Syndrome Type 1 Papillon-League-Psaume Syndrome Ofdi Ofdsi Orofaciodigital Syndrome, Type I
Joubert Syndrome 5	JBTS5 Joubert Syndrome, Type 5
Townes-Brocks Syndrome	Townes Syndrome Renal-Ear-Anal-Radial Syndrome Anus, Imperforate, With Hand, Foot And Ear Anomalies Imperforate Anus-Hand, Foot And Ear Anomalies Syndrome Rear Syndrome Sensorineural Deafness With Imperforate Anus And Hypoplastic Thumbs Tbs Deafness, Sensorineural, With Imperforate Anus And Hypoplastic Thumbs Imperforate Anus With Hand, Foot And Ear Anomalies Anal-Ear-Renal-Radial Malformation Syndrome Deafness-Imperforate Anus-Hypoplastic Thumbs Syndrome Imperforate Anus-Hand And Foot Anomalies Syndrome Sensorineural Deafness-Imperforate Anus-Hypoplastic Thumbs Syndrome Sensorineural Hearing Loss With Imperforate Anus And Hypoplastic Thumbs
Mosaic Variegated Aneuploidy Syndrome	Warburton-Anyane-Yeboa Syndrome Mva Syndrome Mosaic Variegated Aneuplody Microcephaly Syndrome Warburton Anyane Yeboa Syndrome
Senior-Loken Syndrome 1	Senior-Loken Syndrome Renal Dysplasia And Retinal Aplasia Renal-Retinal Syndrome Loken-Senior Syndrome Juvenile Nephronophthisis With Leber Amaurosis SLSN1 Senior-Loken Syndrome-1 Loken Senior Syndrome Senior Loken Syndrome Renal Dysplasia Retinal Aplasia Nephronophthisis With Retinal Dystrophy Renal Dysplasia-Retinal Aplasia Syndrome Slsn
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly
Primary Microcephaly	True Microcephaly Microcephaly, Primary
Nephronophthisis	Medullary Cystic Disease Medullary Cystic Kidney Nph Nphp Kidney Disease, Cystic, Medullary
Asphyxiating Thoracic Dystrophy	Jeune Thoracic Dystrophy Jeune Syndrome Asphyxiating Thoracic Dysplasia Short-Rib Thoracic Dysplasia With Or Without Polydactyly Thoracic Pelvic Phalangeal Dystrophy Asphyxiating Thoracic Chondrodystrophy Atd Chondroectodermal Dysplasia-Like Syndrome Infantile Thoracic Dystrophy Jeune Thoracic Dysplasia Thoracic Asphyxiant Dystrophy Thoracic-Pelvic-Phalangeal Dystrophy Short-Rib Thoracic Dysplasia Without Polydactyly Asphyxiating Thoracic Dystrophy Of The Newborn Asphyxiating Thorax Dystrophy
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Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02145	CCP110 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CCP110	VGNC	VGNC:26981
Felis catus	CCP110	VGNC	VGNC:60570
Rattus norvegicus	CCP110	RGD	RGD:1310509
Macaca mulatta	CCP110	VGNC	VGNC:70846
Mus musculus	CCP110	MGD	MGI:2141942
Canis familiaris	CCP110	VGNC	VGNC:38909
Others	CCP110	NCBI