KIF24 - kinesin family member 24 Gene

Also Known as C9orf48; bA571F15.4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 347240

About KIF24

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:34,252,380-34,333,671 (from NCBI)

This gene has 3 transcripts (splice variants), 168 orthologues and 41 paralogues. Broad expression in testis (RPKM 7.5), bone marrow (RPKM 4.2) and 25 other tissues.

Summary

This gene encodes a member of the Kinesin superfamily of microtubule-based motor proteins which are involved in the intracellular transport of membranous organelles, protein complexes, and mRNAs. They also play critical roles in Mitosis, morphogenesis, and signal transduction. The encoded protein contains an N-terminal sterile alpha motif (SAM) domain and an ATP-binding Kinesin motor domain. It binds centriolar coiled coil protein 110 and centrosomal protein 97 and localizes to the mother centriole to regulate ciliogenesis by controlling microtubule polymerization. [provided by RefSeq, Mar 2017]

KIF24 Products (1)

mRNA	Protein	Name
NM_194313.4	NP_919289.2	kinesin-like protein KIF24

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	26290419	GOA
enables microtubule motor activity	IDA IDA: Inferred from direct assay	21620453	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21620453	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	21620453	GOA
involved in microtubule depolymerization	IDA IDA: Inferred from direct assay	21620453	GOA
involved in negative regulation of cilium assembly	IMP IMP: Inferred from mutant phenotype	30375385	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in centriole	IDA IDA: Inferred from direct assay	21620453	GOA
located in centrosome	IDA IDA: Inferred from direct assay	30375385	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	24421332	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIF24 Protein Structure

SAM_1

Kinesin

0
300
600
900
1200
1368 a.a.

Protein Preferred Names	Protein Names
kinesin-like protein KIF24

KIF24 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KIF24	Q5T7B8	CEP97	Homo sapiens	Q8IW35	Anti Tag CoIP	21620453
Intra	KIF24	Q5T7B8	CEP97	Homo sapiens	Q8IW35	Anti Tag CoIP	24421332
Intra	KIF24	Q5T7B8	CEP97	Homo sapiens	Q8IW35	Anti Bait CoIP	21620453
Intra	KIF24	Q5T7B8	CEP97	Homo sapiens	Q8IW35	Anti Tag CoIP	26496610
Intra	KIF24	Q5T7B8	CEP97	Homo sapiens	Q8IW35	Anti Bait CoIP	24421332
Intra	KIF24	Q5T7B8	CEP97	Homo sapiens	Q8IW35	Anti Tag CoIP	33961781
Intra	KIF24	Q5T7B8	CCP110	Homo sapiens	O43303	Anti Bait CoIP	21620453
Intra	KIF24	Q5T7B8	CCP110	Homo sapiens	O43303	Anti Bait CoIP	24421332
Intra	KIF24	Q5T7B8	CCP110	Homo sapiens	O43303	Anti Tag CoIP	24421332
Intra	KIF24	Q5T7B8	CCP110	Homo sapiens	O43303	Anti Tag CoIP	33961781
Intra	KIF24	Q5T7B8	CCP110	Homo sapiens	O43303	Anti Tag CoIP	21620453
Intra	KIF24	Q5T7B8	NEK2	Homo sapiens	P51955	Anti Bait CoIP	26290419
Intra	KIF24	Q5T7B8	NEK2	Homo sapiens	P51955	Anti Tag CoIP	26290419

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Short-Rib Thoracic Dysplasia 3 With Or Without Polydactyly	Asphyxiating Thoracic Dystrophy 3 Saldino-Noonan Syndrome SRTD3 Atd3 Srps1 Srps3 Verma-Naumoff Syndrome Srps2b Short Rib-Polydactyly Syndrome, Verma-Naumoff Type Short Rib-Polydactyly Syndrome, Type I Polydactyly With Neonatal Chondrodystrophy, Type I Polydactyly With Neonatal Chondrodystrophy, Type Iii Short Rib-Polydactyly Syndrome, Type Iib Short Rib-Polydactyly Syndrome Type 3 Polydactyly With Neonatal Chondrodystrophy Type Iii Short Rib-Polydactyly Syndrome Type Iii Short Rib-Polydactyly Syndrome Type 1 Short Rib-Polydactyly Syndrome, Saldino-Noonan Type Majewski Syndrome Short Rib-Polydactyly Syndrome, Type Iii Type I Short Rib Polydactyly Syndrome Srps Type 3 Short Rib Polydactyly Syndrome Verma Naumoff Type Verma Naumoff Syndrome Polydactyly With Neonatal Chondrodystrophy Type 1 Srps Type 1 Short Rib-Polydactyly Syndrome Saldino-Noonan Type Jatd Jeune Asphyxiating Thoracic Dystrophy Jeune Syndrome 3 Polydactyly With Neonatal Chondrodystrophy Type I Short Rib-Polydactyly Syndrome Type I Short Rib-Polydactyly Syndrome Type Iib Srps Type Iib Srps Type Iii
Orofaciodigital Syndrome I	OFD1 Orofaciodigital Syndrome 1 Oral-Facial-Digital Syndrome, Type I Oral-Facial-Digital Syndrome 1 Ofds I Papillon-Leage And Psaume Syndrome Papillon-Leage-Psaume Syndrome Oral-Facial-Digital Syndrome Type 1 Orofaciodigital Syndrome Type 1 Orofaciodigital Syndromes Orofaciodigital Syndrome Type I Oral-Facial-Digital Syndrome Type I Ofd Syndrome 1 Ofds 1 Oral Facial Digital Syndrome 1 Oral Facial Digital Syndrome Type 1 Papillon-League-Psaume Syndrome Ofdi Ofdsi Orofaciodigital Syndrome, Type I
Joubert Syndrome 23	JBTS23 Joubert Syndrome, Type 23
Mosaic Variegated Aneuploidy Syndrome	Warburton-Anyane-Yeboa Syndrome Mva Syndrome Mosaic Variegated Aneuplody Microcephaly Syndrome Warburton Anyane Yeboa Syndrome
Joubert Syndrome 5	JBTS5 Joubert Syndrome, Type 5
Nephronophthisis	Medullary Cystic Disease Medullary Cystic Kidney Nph Nphp Kidney Disease, Cystic, Medullary
Meckel Syndrome, Type 1	Meckel-Gruber Syndrome Meckel Syndrome Dysencephalia Splanchnocystica Meckel Syndrome 1 MKS1 Mks Gruber Syndrome Meckel-Gruber Syndrome, Type 1 Mes Dysencephalia Splachnocystica Meckel Gruber Syndrome Meckel Syndrome Type 1
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly
Joubert Syndrome 1	Joubert Syndrome Jbts Cerebellooculorenal Syndrome 1 JBTS1 Joubert-Boltshauser Syndrome Cerebelloparenchymal Disorder Iv Cpd4 Cors1 Joubert Syndrome And Related Disorders Jsrd Familial Aplasia Of The Vermis Joubert Syndrome Related Disorders Js Cerebellar Vermis Agenesis Cerebelloparenchymal Disorder 4 Agenesis Of Cerebellar Vermis Cerebello-Oculo-Renal Syndrome Cors Joubert-Bolthauser Syndrome Cpd Iv Classic Joubert Syndrome Joubert Syndrome Type A Pure Joubert Syndrome Cerebello-Oculo-Renal Syndrome 1 Joubert Syndrome-1 Joubert Syndrome, Type 1 Joubert'S Syndrome
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07278	KIF24 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	KIF24	VGNC	VGNC:42399
Bos taurus	KIF24	VGNC	VGNC:30597
Macaca mulatta	KIF24	VGNC	VGNC:73864
Felis catus	KIF24	VGNC	VGNC:63114
Mus musculus	KIF24	MGD	MGI:1918345
Rattus norvegicus	KIF24	RGD	RGD:1307723