PKN2 - protein kinase N2 Gene

Also Known as PAK2; PRK2; STK7; Pak-2; PRKCL2; PRO2042

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5586

About PKN2

Cytogenetic location: 1p22.2 Genomic coordinates (GRCh38): 1:88,684,273-88,836,255 (from NCBI)

This gene has 6 transcripts (splice variants), 287 orthologues and 9 paralogues. Ubiquitous expression in ovary (RPKM 11.1), duodenum (RPKM 10.9) and 25 other tissues.

Summary

Enables RNA polymerase binding activity; histone deacetylase binding activity; and protein serine/threonine kinase activity. Involved in several processes, including apical junction assembly; positive regulation of cell cycle; and positive regulation of viral genome replication. Located in several cellular components, including cleavage furrow; cytoskeleton; and midbody. [provided by Alliance of Genome Resources, Apr 2022]

PKN2 Products (4)

mRNA Protein Name
NM_001320707.2 NP_001307636.1 serine/threonine-protein kinase N2 isoform 2
NM_001320708.2 NP_001307637.1 serine/threonine-protein kinase N2 isoform 3
NM_001320709.2 NP_001307638.1 serine/threonine-protein kinase N2 isoform 4
NM_006256.4 NP_006247.1 serine/threonine-protein kinase N2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase binding IPI
IPI: Inferred from physical interaction
15364941 GOA
enables histone deacetylase binding IDA
IDA: Inferred from direct assay
20188095 GOA
enables kinase activity IDA
IDA: Inferred from direct assay
15364941 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10026169 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
20188095 GOA
Biological Process GO Annotation Evidence References Source
involved in apical junction assembly IMP
IMP: Inferred from mutant phenotype
20974804 GOA
involved in epithelial cell migration IDA
IDA: Inferred from direct assay
21754995 GOA
involved in positive regulation of cytokinesis IMP
IMP: Inferred from mutant phenotype
17332740 GOA
involved in positive regulation of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
17332740 GOA
involved in positive regulation of viral genome replication IMP
IMP: Inferred from mutant phenotype
15364941 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
17332740 GOA
involved in regulation of cell motility IMP
IMP: Inferred from mutant phenotype
21754995 GOA
Cellular Component GO Annotation Evidence References Source
located in apical junction complex IDA
IDA: Inferred from direct assay
20974804 GOA
located in cleavage furrow IDA
IDA: Inferred from direct assay
17332740 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
17332740 GOA
located in lamellipodium IDA
IDA: Inferred from direct assay
11356191 GOA
located in midbody IDA
IDA: Inferred from direct assay
17332740 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11356191 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
15364941 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
23223530 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PKN2 Protein Structure

HR1

HR1: Hr1 repeat (50 - 113)

HR1

HR1: Hr1 repeat (136 - 201)

HR1

HR1: Hr1 repeat (218 - 288)

Pkinase

Pkinase: Protein kinase domain (659 - 916)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (937 - 981)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 984 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase N2

  • PKN gamma

PKN2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PKN2 Q16513 CETN2 Homo sapiens P41208
Anti Tag CoIP
35271311
Intra
PKN2 Q16513 PDK1 Homo sapiens Q15118
Protein Kinase Assay
17110931
Cross
PKN2 Q16513 O92972-PRO_0000278753 Hepatitis C virus O92972-PRO_0000278753
ELISA
15364941
Cross
PKN2 Q16513 O92972-PRO_0000278753 Hepatitis C virus O92972-PRO_0000278753
Anti Bait CoIP
15364941
Cross: Cross-species interaction Intra: Intraspecies interaction

PKN2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83145 PRK2 Antibody (YA2890) WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat
HY-P84612 PRK2 Antibody (YA4309) WB, IHC-P, FC, ELISA Human, Mouse, Rat, Monkey
HY-P84612A PRK2 Antibody (YA4309)(PBS only) WB, IHC-P, FC, ELISA Human, Mouse, Rat, Monkey
HY-P85334 PRK2 Antibody (YA5026) WB; IHC-P; IHC-F; ICC/IF; IF-Tissue; IP; FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations

  • Star Syndrome

  • Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome

  • Syndactyly With Renal And Anogenital Malformations

  • STAR

  • Syndactyly, Telecanthus, Anogenital And Renal Malformations

  • Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations
Bubonic Plague

  • Black Death

  • Plague, Bubonic

  • Plague, Septicemic

  • Pestis Bubonica
Mevalonic Aciduria

  • Mevalonate Kinase Deficiency

  • Mevalonicaciduria

  • Hyperimmunoglobulin D With Periodic Fever

  • MEVA

  • Complete Mevalonate Kinase Deficiency

  • Mva

  • Hyperimmunoglobulinemia D

  • Hyper Igd Syndrome

  • Periodic Fever, Dutch Type

  • Mkd

  • Aciduria, Mevalonic

  • Deficiency Of Mevalonate Kinase
Plague

  • Yersiniosis

  • Yersinia Infections

  • Infection By Yersinia Pestis

  • Pasteurella Pestis Infection

  • Pestilential Fever

  • Yersinia Pestis Infection
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-145899 PKN1/2-IN-1 Inhibitor 99.92% Unkown
HY-RS10607 PKN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18043 Pkn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24517 Pkn2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PKN2 VGNC VGNC:32946
Macaca mulatta PKN2 VGNC VGNC:76015
Canis familiaris PKN2 VGNC VGNC:44612
Felis catus PKN2 VGNC VGNC:69064
Rattus norvegicus PKN2 RGD RGD:620146
Mus musculus PKN2 MGD MGI:109211
Others PKN2 NCBI