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  3. GLP-1(32-36)amide

GLP-1(32-36)amide 

Cat. No.: HY-P3102 Purity: 98.43%
Handling Instructions

GLP-1(32-36)amide, a pentapeptide, derived from the C terminus of the glucoregulatory hormone GLP-1. GLP-1(32-36)amide could inhibit weight gain and modulate whole body glucose metabolism in diabetic mice.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

GLP-1(32-36)amide Chemical Structure

GLP-1(32-36)amide Chemical Structure

CAS No. : 1417302-71-6

Size Price Stock Quantity
5 mg USD 220 In-stock
Estimated Time of Arrival: December 31
10 mg USD 372 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

GLP-1(32-36)amide, a pentapeptide, derived from the C terminus of the glucoregulatory hormone GLP-1. GLP-1(32-36)amide could inhibit weight gain and modulate whole body glucose metabolism in diabetic mice[1][2].

In Vitro

GLP-1(32-36)amide (0.1-10 μM; 24 h) retains cell viability and decreases apoptosis against Streptozotocin (STZ; 1 μM) in INS‐1 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: INS‐1 cells
Concentration: 0.1, 1, 10 μM
Incubation Time: 24 hours
Result: Decreased cell viability only approximately 30% in 0.1 μM and approximately 20% in ≥1 μM while approximately 45% in saline-treated controls.
In Vivo

GLP-1(32-36)amide (1 μmol/kg; i.p. once daily for 21 d) protects islet from damage, inhibits weight gain, and relieves symptoms of polydipsia in diabetic mice[2].
GLP-1(32-36)amide (1 μmol/kg; a single i.p.) slightly reduces the mean glucose lever at 30 min after the challenge of glucose in normal mice[2].
GLP-1(32-36)amide (50-70 nmol/kg/d; infusion for 12-16 weeks) prevents the development of diet-induced obesity and hepatic steatosis in high fat-fed mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male KM mice (6-8 weeks; 18-22 g) injected with STZ[2]
Dosage: 1 μmol/kg
Administration: I.p. once daily for 21 days
Result: Significantly lowered the cumulative values of food and water intake.
Lowered fasting glucose.
Reduced the level of Hemoglobin A1c (HbA1c).
Improved glucose tolerance.
Suppressed body weight gain.
Molecular Weight

570.73

Formula

C25H50N10O5

CAS No.
Sequence

Leu-Val-Lys-Gly-Arg-NH2

Sequence Shortening

LVKGR-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -80°C 2 years
-20°C 1 year
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (438.04 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7521 mL 8.7607 mL 17.5214 mL
5 mM 0.3504 mL 1.7521 mL 3.5043 mL
10 mM 0.1752 mL 0.8761 mL 1.7521 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.64 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.64 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.64 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
GLP-1(32-36)amide
Cat. No.:
HY-P3102
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