グルコースオキシダーゼ  (Synonyms: Glucose oxidase)

Glucose oxidase is used in the food and beverage industry as a preservative and stabilizer and is commonly derived from the fungus Aspergillus niger. Glucose oxidase can react with intracellular glucose and oxygen (O₂) to produce hydrogen peroxide (H₂O₂) and gluconic acid, which can cut off the nutrition source of cancer cells and consequently inhibit their proliferation^[1][2][3].

Glucose oxidase is a subset of oxidoreductase enzymes that catalyzes the transfer of electrons from an oxidant to a reductant. Glucose oxidases use oxygen as an external electron acceptor that releases hydrogen peroxide (H₂O₂). Glucose oxidase has many applications in commercial processes, including improving the color and taste, increasing the persistence of food materials, removing the glucose from the dried egg, and eliminating the oxygen from different juices and beverages^[4].
Product Information
Theoretical molecular weight: 160 kDa
pH effective range: 4.0-8.0, optimum pH 5.5
Optimum temperature: 30°C-45°C
Temperature stability: <50°C (pH 5.0, 15 min)
Isoelectric point: 4.2
No activator required, inhibitors are Ag⁺, Hg²⁺, Cu²⁺

Instructions
Soluble in water, or according to the specific experimental reference (e.g. 1.0 mg/mL in 50 mM sodium acetate buffer, pH 5.7)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

9001-37-0

Solid

Light yellow to yellow

[Glucose oxidase]

1.1.3.4

≥300 U/mg protein

One unit is defined as the amount of enzyme that oxidize 1 μmol of glucose per min at pH 5.7 at 37°C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Konishi T, et al. Safety evaluation of glucose oxidase from Penicillium chrysogenum [published correction appears in Regul Toxicol Pharmacol. 2013 Aug;66(3):300]. Regul Toxicol Pharmacol. 2013;66(1):13-23.  [Content Brief]

  [2]. Leskovac V, et al. Glucose oxidase from Aspergillus niger: the mechanism of action with molecular oxygen, quinones, and one-electron acceptors. Int J Biochem Cell Biol. 2005;37(4):731-750.  [Content Brief]

  [3]. Wang M, et al. Recent Advances in Glucose-Oxidase-Based Nanocomposites for Tumor Therapy. Small. 2019;15(51):e1903895.  [Content Brief]

  [4]. Khatami SH, et al. Glucose oxidase: Applications, sources, and recombinant production [published online ahead of print, 2021 Apr 11]. Biotechnol Appl Biochem. 2021;10.1002/bab.2165.  [Content Brief]