Aspartate aminotransferase, porcine heart  (Synonyms: EC 2.6.1.1, porcine heart; GOT, porcine heart; AST, porcine heart)

Aspartate aminotransferase (EC 2.6.1.1), porcine heart is a metabolic regulator with the highest activity in the heart, liver and skeletal muscle. Aspartate aminotransferase, porcine heart comprises two isozymes: the cytoplasmic form (AST1) and the mitochondrial form (AST2). By catalyzing reversible transamination reactions between oxaloacetate, L-glutamate and other substances, it is deeply involved in key physiological processes such as amino acid metabolism, the tricarboxylic acid cycle and neurotransmitter synthesis. Aspartate aminotransferase, porcine heart also provides substrate support for the synthesis of urea and purines/pyrimidines. Aspartate aminotransferase, porcine heart is a serum marker reflecting cardiac and hepatic injury, and its abnormal levels are also closely associated with myocardial infarction, cardiovascular diseases and various cancers^[1][2][3].

Aspartate aminotransferase, porcine heart has increased synthesis and release in adipocytes treated with rosiglitazone (HY-17386), which catalyzes the aminotransferase reaction between aspartate and α-ketoglutarate^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

9000-97-9

Solid

Light yellow to yellow

[Aspartate aminotransferase, porcine heart]

2.6.1.1

≥100 U/mg soild

One unit is defined as the amount of enzyme that can convert 1 μmol of α-ketoglutarate to Lglutamate per minute under conditions of pH 7.5 and 37°C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ndrepepa G. Aspartate aminotransferase and cardiovascular disease—a narrative review[J]. Journal of Laboratory and Precision Medicine, 2021, 6.

  [2]. Chambers DA, et al. A longitudinal study of aspartate aminotransferase in human gingival crevicular fluid. J Periodontal Res. 1991;26(2):65-74.

  [3]. Otto-Ślusarczyk D, et al. Aminotransferaza asparaginianowa-kluczowy enzym w metabolizmie ogólnoustrojowym człowieka[J]. Advances in Hygiene & Experimental Medicine/Postepy Higieny i Medycyny Doswiadczalnej, 2016, 70.

  [4]. Ogbuagu E O, et al. Effect of Monosodium glutamate on body weight and alanine aminotransferase activity in wistar rats[J]. International Research Journal of Gastroenterology and Hepatology, 2019, 2(2): 1-8.