2. Metabolic Enzyme/Protease
  3. Aminotransferases (Transaminases)
  4. Aspartate aminotransferase, Human liver

Aspartate aminotransferase, Human liver  (Synonyms: EC 2.6.1.1, Human liver; GOT, Human liver; AST, Human liver)

Cat. No.: HY-P3016B
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Aspartate aminotransferase (EC 2.6.1.1), Human liver is a metabolic regulator with the highest activity in the heart, liver and skeletal muscle. Aspartate aminotransferase, Human liver comprises two isozymes: the cytoplasmic form (AST1) and the mitochondrial form (AST2). By catalyzing reversible transamination reactions between oxaloacetate, L-glutamate and other substances, it is deeply involved in key physiological processes such as amino acid metabolism, the tricarboxylic acid cycle and neurotransmitter synthesis. Aspartate aminotransferase, Human liver also provides substrate support for the synthesis of urea and purines/pyrimidines. Aspartate aminotransferase, Human liver is a serum marker reflecting cardiac and hepatic injury, and its abnormal levels are also closely associated with myocardial infarction, cardiovascular diseases and various cancers.

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Aspartate aminotransferase, Human liver

Aspartate aminotransferase, Human liver Chemical Structure

CAS No. : 9000-97-9

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Aspartate aminotransferase, Human liver Related Antibodies

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Description

Aspartate aminotransferase (EC 2.6.1.1), Human liver is a metabolic regulator with the highest activity in the heart, liver and skeletal muscle. Aspartate aminotransferase, Human liver comprises two isozymes: the cytoplasmic form (AST1) and the mitochondrial form (AST2). By catalyzing reversible transamination reactions between oxaloacetate, L-glutamate and other substances, it is deeply involved in key physiological processes such as amino acid metabolism, the tricarboxylic acid cycle and neurotransmitter synthesis. Aspartate aminotransferase, Human liver also provides substrate support for the synthesis of urea and purines/pyrimidines. Aspartate aminotransferase, Human liver is a serum marker reflecting cardiac and hepatic injury, and its abnormal levels are also closely associated with myocardial infarction, cardiovascular diseases and various cancers[1][2][3].

In Vitro

Aspartate aminotransferase, Human liver has increased synthesis and release in adipocytes treated with rosiglitazone (HY-17386), which catalyzes the aminotransferase reaction between aspartate and α-ketoglutarate[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Aspartate aminotransferase, Human liver Related Antibodies
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[Aspartate aminotransferase, Human liver]
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Aspartate aminotransferase, Human liver Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aspartate aminotransferase, Human liver9000-97-9EC 2.6.1.1, Human liver GOT, Human liver AST, Human liverAminotransferases (Transaminases)IRE1α/c-Jun signaling pathwayisoniazidAST1maleateadipocytesAspartate aminotransferaseHuman liverAST2aminooxyacetateHepG2 hepatoma cellssuccinateInhibitorinhibitorinhibit

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