Aspartate aminotransferase, Human liver  (Synonyms: EC 2.6.1.1, Human liver; GOT, Human liver; AST, Human liver)

Aspartate aminotransferase (EC 2.6.1.1), Human liver is a metabolic regulator with the highest activity in the heart, liver and skeletal muscle. Aspartate aminotransferase, Human liver comprises two isozymes: the cytoplasmic form (AST1) and the mitochondrial form (AST2). By catalyzing reversible transamination reactions between oxaloacetate, L-glutamate and other substances, it is deeply involved in key physiological processes such as amino acid metabolism, the tricarboxylic acid cycle and neurotransmitter synthesis. Aspartate aminotransferase, Human liver also provides substrate support for the synthesis of urea and purines/pyrimidines. Aspartate aminotransferase, Human liver is a serum marker reflecting cardiac and hepatic injury, and its abnormal levels are also closely associated with myocardial infarction, cardiovascular diseases and various cancers^[1][2][3].

Aspartate aminotransferase, Human liver has increased synthesis and release in adipocytes treated with rosiglitazone (HY-17386), which catalyzes the aminotransferase reaction between aspartate and α-ketoglutarate^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

9000-97-9

[Aspartate aminotransferase, Human liver]

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• [1]. Ndrepepa G. Aspartate aminotransferase and cardiovascular disease—a narrative review[J]. Journal of Laboratory and Precision Medicine, 2021, 6.

  [2]. Chambers DA, et al. A longitudinal study of aspartate aminotransferase in human gingival crevicular fluid. J Periodontal Res. 1991;26(2):65-74.

  [3]. Otto-Ślusarczyk D, et al. Aminotransferaza asparaginianowa-kluczowy enzym w metabolizmie ogólnoustrojowym człowieka[J]. Advances in Hygiene & Experimental Medicine/Postepy Higieny i Medycyny Doswiadczalnej, 2016, 70.

  [4]. Ogbuagu E O, et al. Effect of Monosodium glutamate on body weight and alanine aminotransferase activity in wistar rats[J]. International Research Journal of Gastroenterology and Hepatology, 2019, 2(2): 1-8.