2. Metabolic Enzyme/Protease
  3. HIF/HIF Prolyl-Hydroxylase
  4. HIF-2α-IN-9

HIF-2α-IN-9 (compound 35r) is an inhibitor ofHIF-2α. HIF-2α-IN-9 inhibits VEGF-A (IC50=305 nM), and regulates growth-promoting genes in tumor cells, reactivates macrophage-mediated tumor immunity.

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HIF-2α-IN-9

HIF-2α-IN-9 화학구조

CAS No. : 2648334-36-3

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HIF-2α-IN-9 Related Antibodies

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제품 설명

HIF-2α-IN-9 (compound 35r) is an inhibitor ofHIF-2α. HIF-2α-IN-9 inhibits VEGF-A (IC50=305 nM), and regulates growth-promoting genes in tumor cells, reactivates macrophage-mediated tumor immunity[1].

IC50 & Target

HIF-2α[1]
Cellular Effect
Cell Line Type Value Description References
J774.A1 IC50
80 1
Compound: 35r
Antitumor activity against mouse J774.A1 cells assessed as downregulation of IL-4 stimulated Arg1 mRNA expression incubated for 48 hrs by qRT-PCR analysis
Antitumor activity against mouse J774.A1 cells assessed as downregulation of IL-4 stimulated Arg1 mRNA expression incubated for 48 hrs by qRT-PCR analysis
[PMID: 37403966]
J774.A1 IC50
80 1
Compound: 35r
Antitumor activity against mouse J774.A1 cells assessed as downregulation of IL-4 stimulated Arg1 mRNA expression incubated for 48 hrs by qRT-PCR analysis
Antitumor activity against mouse J774.A1 cells assessed as downregulation of IL-4 stimulated Arg1 mRNA expression incubated for 48 hrs by qRT-PCR analysis
[PMID: 37403966]
분자량

380.35

화학식

C12H13F5O4S2
CAS No.
SMILES

FC1(F)[C@@H](O)C2=C(S(=O)(C)=O)SC(OC[C@H](C)C(F)(F)F)=C2C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
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HIF-2α-IN-9 Related Classifications

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Keywords:

HIF-2α-IN-92648334-36-3HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHInhibitorinhibitorinhibit

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HIF-2α-IN-9
Cat. No.:
HY-149886
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