2. Metabolic Enzyme/Protease Apoptosis
  3. Thrombin Apoptosis
  4. Hirudin

Hirudin is a thrombin inhibitor with blood anticoagulant property. Hirudin has potent anti-thrombotic, wound repair, anti-fibrosis, anti-tumor and anti-hyperuricemia effects. Hirudin also affects diabetic complications, cerebral hemorrhage, and others.

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Hirudin

Hirudin 構造式

CAS 番号 : 8001-27-2

容量 価格（税別） 在庫状況 数量
500 μg $675 在庫あり
1 mg $1080 在庫あり
5 mg $3250 在庫あり
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Based on 3 publication(s) in Google Scholar

Hirudin 関連抗体

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製品説明

Hirudin is a thrombin inhibitor with blood anticoagulant property. Hirudin has potent anti-thrombotic, wound repair, anti-fibrosis, anti-tumor and anti-hyperuricemia effects. Hirudin also affects diabetic complications, cerebral hemorrhage, and others[1].

体外実験

Hirudin inhibits the activity of thrombin, deprives the ability of thrombin to cleave fibrinogen, prevents the formation of fibrin and the cross-linking polymerization process of fibrin monomer in internal and external coagulation pathway[1].
Hirudin reduces cell apoptosis of human microvascular endothelial cells (HMVECs) and suppresses the expression of p-JAK2 via antagonizing thrombin[1].
Hirudin inhibits VEGF-Notch pathway and cell proliferation of HMVECs at high doses[1].
Hirudin (3-10 mg/mL) reverses the abnormal proliferation and fibrosis in HK-2 cells caused by TGF-β1[1].
Hirudin depresses the myocardial fibroblasts induced by angiotensin II by dose-dependently inhibits oxidative stress, regulates fibrosis-related factors, and represses the ERK1/2 pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hirudin 関連抗体
体内実験

Hirudin increases the viability of rat random skin flap and reduces inflammatory responses[1].
Hirudin promotes the wound healing in SD rats after laser surgery[1].
Hirudin (10 and 15 mg/kg; i.g. once daily for 21 days) improves renal interstitial fibrosis to reduce renal tubule injury and inflammation in unilateral ureteral obstruction (UUO) mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male balb/c mice with underwent unilateral ureteral ligation (UUO)[2]
Dosage: 10 and 15 mg/kg
Administration: Oral gavage; 10 and 15 mg/kg, once daily for 21 days
Result: Reduced renal damages and suppressed the upregulation of α-SMA, collagen deposition in UUO mice. Increased the level of fibrosis (collagen-I, FN, α-SMA), N-cad, slug and E-cad in UUO mice. Decreased the level of IL-1β, IL-6 and TNF-α, apoptosis of renal tubular cells in UUO mice. Decreased the expression of inflammatory factors, the occurrence of EMT, the incidence of fibrosis and the apoptosis of TGF-β-induced renal tubular epithelial cell.
臨床実験
CAS 番号
Appearance

Liquid

Color

Colorless to light yellow

Structure Classification
Initial Source

leech
輸送条件

Shipping with dry ice.
保管条件

-80°C
純度とドキュメンテーション

純度: 95.0%

COA (300 KB)

取扱説明書 (2659 KB)
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Hirudin Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hirudin8001-27-2ThrombinApoptosisanticoagulantanti-thromboticJAK2HMVECVEGFHK-2ERK1/2angiotensin IIUOOratInhibitorinhibitorinhibit

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製品名:
Hirudin
製品番号:
HY-P2813
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