2. JAK/STAT Signaling Stem Cell/Wnt
  3. STAT
  4. HJC0149

HJC0149 is a potent and orally active inhibitor of signal transducer and activator of transcription 3 (STAT3).

Para uso exclusivo en investigación. No vendemos a pacientes.

HJC0149

HJC0149 Estructura química

No. CAS : 1430330-65-6

Tamaño Stock
50 mg   Obtener un presupuesto  
100 mg   Obtener un presupuesto  
250 mg   Obtener un presupuesto  

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

HJC0149 Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas STAT:

Ver todas las isoformas
STAT3 STAT5 STAT6 STAT1

  • Actividad biológica

  • Pureza y Documentación

  • Referencias

  • Revisión del cliente

Descripciòn

HJC0149 is a potent and orally active inhibitor of signal transducer and activator of transcription 3 (STAT3)[1].

Cellular Effect
Cell Line Type Value Description References
ASPC1 IC50
1.92 μM
Compound: 1, HJC0149
Antiproliferative activity against human AsPC1 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay
Antiproliferative activity against human AsPC1 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay
[PMID: 24904966]
ASPC1 IC50
1.92 μM
Compound: 12
CYtotoxicity against human AsPC1 cells by MTS assay
CYtotoxicity against human AsPC1 cells by MTS assay
[PMID: 23416191]
MCF7 IC50
0.91 μM
Compound: 1, HJC0149
Antiproliferative activity against ER-positive human MCF7 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay
Antiproliferative activity against ER-positive human MCF7 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay
[PMID: 24904966]
MCF7 IC50
0.91 μM
Compound: 12
CYtotoxicity against ER-positive human MCF7 cells by MTS assay
CYtotoxicity against ER-positive human MCF7 cells by MTS assay
[PMID: 23416191]
MDA-MB-231 IC50
1.64 μM
Compound: 1, HJC0149
Antiproliferative activity against ER-negative and triple-negative human MDA-MB-231 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay
Antiproliferative activity against ER-negative and triple-negative human MDA-MB-231 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay
[PMID: 24904966]
MDA-MB-231 IC50
1.64 μM
Compound: 12
CYtotoxicity against ER-negative human MDA-MB-231 cells by MTS assay
CYtotoxicity against ER-negative human MDA-MB-231 cells by MTS assay
[PMID: 23416191]
PANC-1 IC50
2.34 μM
Compound: 1, HJC0149
Antiproliferative activity against human PANC1 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay
Antiproliferative activity against human PANC1 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay
[PMID: 24904966]
PANC-1 IC50
2.34 μM
Compound: 12
CYtotoxicity against human PANC1 cells by MTS assay
CYtotoxicity against human PANC1 cells by MTS assay
[PMID: 23416191]
Peso molecular

335.76

Fòrmula

C15H10ClNO4S
No. CAS
SMILES

OC1=C(C=C(C=C1)Cl)C(NC2=CC3=C(C=C2)C=CS3(=O)=O)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

HJC0149 Related Classifications

  • Calculadora de molaridad

  • Calculadora de dilución

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HJC01491430330-65-6HJC 0149HJC-0149STATAnticancer agentsBreast cancerOral bioavailabilityPancreatic cancerSTAT3 inhibitorsInhibitorinhibitorinhibit

Productos vistos recientemente:

Consulta en línea

Your information is safe with us. * Required Fields.

Nombre del producto

  

Requested Quantity *

Nombre del solicitante *

 

Saludo

Direcciòn del E-mail *

 

Número de teléfono *

Department

 

Nombre de la Organizaciòn *

City

Provincia

Country or Region *

      

Observaciones

Consulta para venta a granel

Inquiry Information

Nombre del producto:
HJC0149
Cat. No.:
HY-116278
Cantidad:
MCE Japan Authorized Agent:

Revisión del cliente

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Nombre del producto

  

Lot #

Nombre del solicitante *

 

Direcciòn del E-mail *

Número de teléfono

 

Department *

Nombre de la Organizaciòn *

 

Country or Region *

Observaciones

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.