2. Immunology/Inflammation
  3. Interleukin Related
  4. IL17A-IN-1

IL17A-IN-1 (compound 72) is an orally active Interleukin 17A inhibitor. IL17A-IN-1 can be used in the study of inflammatory and autoimmune diseases (plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis, etc.), as well as cancer.

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IL17A-IN-1

IL17A-IN-1 Chemische Struktur

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IL17A-IN-1 Related Antibodies

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Beschreibung

IL17A-IN-1 (compound 72) is an orally active Interleukin 17A inhibitor. IL17A-IN-1 can be used in the study of inflammatory and autoimmune diseases (plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis, etc.), as well as cancer[1].

Cellular Effect
Cell Line Type Value Description References
HeLa IC50
0.005 3
Compound: 72
Inhibition of IL171A/TNF-stimulated human HeLa cells transfected with IL17 target gene lipocalin 2 (LCN2) promotor by measuring luminescence by multimode plate reader
Inhibition of IL171A/TNF-stimulated human HeLa cells transfected with IL17 target gene lipocalin 2 (LCN2) promotor by measuring luminescence by multimode plate reader
[PMID: 38574366]
In Vitro

IL17A-IN-1 inhibits Hela cells with an IC50 value of 0.005 µM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IL17A-IN-1 Related Antibodies
In Vivo

IL17A-IN-1 (10 mg/kg; p.o.; single dose) inhibits plasma CXCL1 secretion in hIL17A-induced mouse (IL17 receptor-containing mouse) CXCL1 PD model[1]. (Subcutaneous injection of recombinant human IL17A into mice induces plasma CXCL1 secretion).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice (hIL17A-induced mouse CXCL1 PD model)[1].
Dosage: 10 mg/kg
Administration: Oral administration; single dose
Result: Inhibited 53% of CXCL1 secretion in hIL17A-induced mouse CXCL1 PD model.
Animal Model: Male Sprague-Dawley rats; 360-460 g[1].
Dosage: 0.3 mg/kg
Administration: Intravenous injection; single dose
Result: 1.19 Pharmacokinetic Parameters of IL17A-IN-1 in male Sprague-Dawley rats[1].
IV (0.3 mg/kg)
Vss (L/kg) 5.0
t1/2 (h) 3.6
CLp/CLp,u (L/h/kg) 1.1/6.1
Molekulargewicht

612.55

Formel

C30H35Cl2N7O3
SMILES

CN1CCC(N2CC3=NC([C@H](C)NC([C@@]4(NC(C5=CC(Cl)=C(Cl)N5)=O)C[C@H](OC4)C6=CC=CC=C6)=O)=NC=C3C2)CC1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
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IL17A-IN-1 Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IL17A-IN-1Interleukin RelatedILHelaplaque psoriasispsoriatic arthritisankylosing spondylitiscancertumorautoimmuneinflammationInhibitorinhibitorinhibit

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