1. JAK/STAT Signaling
    Stem Cell/Wnt
  2. STAT
  3. inS3-54A18

inS3-54A18 

Cat. No.: HY-103128 Purity: 99.83%
Handling Instructions

inS3-54A18 is a potent STAT3 inhibitor, with anti-cancer properties.

For research use only. We do not sell to patients.

inS3-54A18 Chemical Structure

inS3-54A18 Chemical Structure

CAS No. : 328998-53-4

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 158 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 158 In-stock
Estimated Time of Arrival: December 31
Solid
2 mg USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 192 In-stock
Estimated Time of Arrival: December 31
10 mg USD 312 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1140 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1920 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

inS3-54A18 is a potent STAT3 inhibitor, with anti-cancer properties.

IC50 & Target

STAT3

 

In Vitro

inS3-54A18 (5 μM) reduces wound healing to 64% and 76% for A549 and MDA-MB-231 cells, respectively. inS3-54A18 at 10 μM further reduces the healing to 47% and 39%, respectively. inS3-54A18 inhibits the expression of STAT3 downstream target genes and the binding of STAT3 to its endogenous target sequences. inS3-54A18 does not affect the constitutive or IL-6-induced STAT3 activation (Tyr705 phosphorylation) but represses STAT3 target gene (survivin) expression[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

inS3-54A18 (200 mg/kg, p.o.) inhibits tumor growth, metastasis and expression of STAT3 target genes in a mouse xenograft model of A549 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

373.83

Formula

C₂₃H₁₆ClNO₂

CAS No.
SMILES

O=C1N(C2=CC=C(O)C=C2)C(C3=CC=CC=C3)=C/C1=C/C4=CC=C(Cl)C=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 150 mg/mL (401.25 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6750 mL 13.3751 mL 26.7501 mL
5 mM 0.5350 mL 2.6750 mL 5.3500 mL
10 mM 0.2675 mL 1.3375 mL 2.6750 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Briefly, 5×106 A549 cells are injected subcutaneously in the flanks of 5-6-week-old male NOD/SCID mice. When the tumor volume reach about 50.0 mm3, the mice are randomized using online program into two different groups (6/group) with one group treated by formulation vehicle control and the other by A18 at 200 mg/kg with oral dosing 2-3 times a week for 4 weeks. One mouse in each group dies during the study and is eliminated. Tumor volume and body weight of the remaining five mice in each group are measured twice a week without blinding. On the thirty-fifth day after implant, mice are euthanized and the tumor tissues are harvested and weighed. Necropsy is also performed to determine changes in the heart, lungs, kidneys, liver and spleen.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: 99.83%

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Keywords:

inS3-54A18STATInhibitorinhibitorinhibit

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Cat. No.:
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