2. Metabolic Enzyme/Protease
  3. Apolipoprotein
  4. Inaxaplin

Inaxaplin (VX-147) is an orally active apolipoprotein L1 (APOL1) function inhibitor (WO2020131807, compound 2). Inaxaplin can be used for the research of kidney disease.

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Inaxaplin

Inaxaplin Chemical Structure

CAS No. : 2446816-88-0

Size Prix Stock Quantité
Échantillon gratuit (0.1 - 0.2 mg)   Appliquer maintenant  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
5 mg En stock
10 mg En stock
25 mg En stock
50 mg En stock
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200 mg   Obtenir un devis  
500 mg   Obtenir un devis  

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Inaxaplin Related Antibodies

Top Publications Citing Use of Products

Voir tous les produits spécifiques à Isoform Apolipoprotein:

Voir toutes les isoformes
apoE apoB apoA1 apoA2 apoA4 apoC1 apoC2 apoC3

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Description

Inaxaplin (VX-147) is an orally active apolipoprotein L1 (APOL1) function inhibitor (WO2020131807, compound 2). Inaxaplin can be used for the research of kidney disease[1].

IC50 & Target

APOL1[1]
In Vitro

Inaxaplin is an apolipoprotein L1 function inhibitor[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Inaxaplin Related Antibodies
Essai clinique
Masse moléculaire

417.38

Formule

C21H18F3N3O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H](CNC1=O)[C@@H]1NC(CCC(C2=CC(F)=C3)=C(C4=CC=C(C=C4)F)NC2=C3F)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvant et solubilité
In Vitro: 

DMSO : 50 mg/mL (119.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3959 mL 11.9795 mL 23.9590 mL
5 mM 0.4792 mL 2.3959 mL 4.7918 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculateur de molarité

  • Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureté et documentation
Références

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3959 mL 11.9795 mL 23.9590 mL 59.8975 mL
5 mM 0.4792 mL 2.3959 mL 4.7918 mL 11.9795 mL
10 mM 0.2396 mL 1.1979 mL 2.3959 mL 5.9897 mL
15 mM 0.1597 mL 0.7986 mL 1.5973 mL 3.9932 mL
20 mM 0.1198 mL 0.5990 mL 1.1979 mL 2.9949 mL
25 mM 0.0958 mL 0.4792 mL 0.9584 mL 2.3959 mL
30 mM 0.0799 mL 0.3993 mL 0.7986 mL 1.9966 mL
40 mM 0.0599 mL 0.2995 mL 0.5990 mL 1.4974 mL
50 mM 0.0479 mL 0.2396 mL 0.4792 mL 1.1979 mL
60 mM 0.0399 mL 0.1997 mL 0.3993 mL 0.9983 mL
80 mM 0.0299 mL 0.1497 mL 0.2995 mL 0.7487 mL
100 mM 0.0240 mL 0.1198 mL 0.2396 mL 0.5990 mL
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Inaxaplin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Inaxaplin2446816-88-0VX-147VX147VX 147ApolipoproteinapolipoproteinkidneyfunctionFSGSNDKDInhibitorinhibitorinhibit

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