2. Protein Tyrosine Kinase/RTK
  3. Insulin Receptor
  4. Insulin degludec

Insulin degludec is an ultra-long-acting form of insulin used for the research of hyperglycemia caused by type 1 and type 2 dabetes. Insulin degludec shows binding efficiency with an IC50 value of 19.59 nM for insulin receptor. Insulin degludec can be used for the research of type 1 and type 2 diabetes.

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Insulin degludec

Insulin degludec 構造式

CAS 番号 : 844439-96-9

容量 価格（税別） 在庫状況 数量
5 mg $220 在庫あり
10 mg $350 在庫あり
25 mg $700 在庫あり
50 mg $1100 在庫あり
100 mg $1650 在庫あり
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500 mg   お問い合わせ  

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Insulin degludec 関連抗体

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製品説明

Insulin degludec is an ultra-long-acting form of insulin used for the research of hyperglycemia caused by type 1 and type 2 dabetes. Insulin degludec shows binding efficiency with an IC50 value of 19.59 nM for insulin receptor. Insulin degludec can be used for the research of type 1 and type 2 diabetes[1][2].

IC50 & Target

IC50: 19.59 nM/L (insulin receptor)[2]
体外実験

Insulin degludec (0.001-1000 nM; 12 h) binds with insulin receptor with an IC50 value of 19.59 nM[2].
Insulin degludec (200 nM; 10 min) increases glucose uptake in HL-1 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Insulin degludec 関連抗体

Western Blot Analysis[2]

Cell Line: HL-1 cardiomyocytes
Concentration: 200 nM
Incubation Time: 0-60 min
Result: Decreased the level of Akt phosphorylation after 5 and 10 min treatment.
体内実験

Insulin degludec (5 U/kg; s.c. once daily for 30 days) affects glucose homeostasis and liver metabolism in diabetic mice undergoing insulin-induced hypoglycemia[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss mice with diabetes[1]
Dosage: 5 U/kg
Administration: Subcutaneous injection; 5 U/kg once daily for 30 days
Result: Showed a fast response to insulin-induced hypoglycemia with a glycemic level at or slightly under 100 mg/dl after 60 min and this response effect can be abolished by cortisol. Diminished rates of glucose production and showed a low lactate production in livers. Increased the number of hepatocytes.
臨床実験
CAS 番号
Appearance

Solid

Color

White to off-white

輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

polypeptide, sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (polypeptide, sealed storage, away from moisture and light, under nitrogen)
溶剤 & 溶解度
体外: 

0.1 M HCl : 50 mg/mL (ultrasonic and adjust pH to 2 with 0.1 M HCl)

H2O : 50 mg/mL (Need ultrasonic)

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純度とドキュメンテーション

純度: 99.92%

COA (243 KB) RP-HPLC (223 KB)

取扱説明書 (2659 KB)
参考文献
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Insulin degludec Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Insulin degludec844439-96-9Insulin Receptorcardiac actioninsulin analoguesgluconeogenesisglutamine dipeptideinsulin-induced hypoglycemialiver metabolismtype I diabetesInhibitorinhibitorinhibit

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