1. GPCR/G Protein
    Neuronal Signaling
  2. Sigma Receptor
  3. IPAG

IPAG 

Cat. No.: HY-100985
Handling Instructions

IPAG is a potent sigma-1 receptor antagonist with a pKi of 4.3. IPAG induces apoptosis.

For research use only. We do not sell to patients.

IPAG Chemical Structure

IPAG Chemical Structure

CAS No. : 193527-91-2

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Description

IPAG is a potent sigma-1 receptor antagonist with a pKi of 4.3[1]. IPAG induces apoptosis[2].

In Vitro

Sigma1 inhibition by IPAG caused the autolysosomal degradation of PD-L1 in PC3 (hormone-insensitive prostate cancer) and MDA-MB-231 (triple-negative breast cancer) cell lines and reduced the levels of functional PD-L1 on the surface of the cells[2].
IPAG treatment produces a mean of 100±8 μg per 106 cells. IPAG can inhibit cell proliferation. Treatment with IPAG decreases cell mass[3].
IPAG treatment suppresses phosphorylation of translational regulator proteins p70S6K, S6, and 4E-BP1[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: T47D cells
Concentration: 10 μM
Incubation Time: 24 hours
Result: The mean forward scatter height (FSC-H) of DMSO (control) measured 412±5, whereas the mean FSC-H of IPAG treated cells was 390±4.

Western Blot Analysis[3]

Cell Line: T47D cells
Concentration: 10 μM
Incubation Time:
Result: Decreased levels of phospho-threonine 389-p70S6Kinase (P-S6K), phospho-serine 235/236-ribosomal S6 (P-S6), and phospho-serine 65-4E-BP1 (P-4E-BP1).
Molecular Weight

395.28

Formula

C₁₇H₂₂IN₃

CAS No.
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IPAG
Cat. No.:
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