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isatin-

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By Targets:	Amylases (1) Apoptosis (2) Atg8/LC3 (1) Autophagy (1) Biochemical Assay Reagents (2) Drug Metabolite (1) Glycosidase (2) HSV (1) JAK (1) Monoamine Oxidase (3) Orthopoxvirus (1) p62 (1) Parasite (1) Reference Standards (2)
By Research Areas:	Cancer (3) Cardiovascular Disease (2) Endocrinology (1) Infection (2) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (3)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y0265

*Isatin* Indoline-2,3-dione	Monoamine Oxidase Apoptosis	Cardiovascular Disease Neurological Disease Cancer
Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC₅₀ of 3 μM. Also binds to central benzodiazepine receptors (IC₅₀ against clonazepam, 123 μM) . Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity . Shows effect on the serotonergic system .

HY-W291131

Isatin-β-thiosemicarbazone IBT	HSV Orthopoxvirus	Infection
Isatin-β-thiosemicarbazone is a potent anti-poxvirus agent (including monkeypox virus, orthopoxvirus, vaccinia virus, etc). Isatin-β-thiosemicarbazone also is a potent herpes simplex virus (HSV) inhibitor. Isatin-β-thiosemicarbazone exhibits

HY-W007719

7-Methylisatin	Biochemical Assay Reagents	Others
7-Methylisatin is a derivative of Isatin (HY-Y0265) and can be utilized as a molecular block .

HY-151935

Antileishmanial agent-13	Parasite	Infection
Antileishmanial agent-13 is a quinoline-isatin hybrid, acts as an antileishmanial agent against L. Major Leishmania strain. Antileishmanial agent-13 acquires the antileishmanial activity via the anti-folate mechanism. Antileishmanial agent-13 has potent inhibition against both promastigote and amastigote forms with IC₅₀s of 0.604 μM and 0.508 μM, respectively .

HY-W046786

Benzylisatin	Biochemical Assay Reagents	Others
Benzylisatin is a biologically potent derivative of isatin. Benzylisatin is used to prepare many new biologically potent Schiff bases and complexes suitable for medicinal purposes .

HY-Y0265R

Isatin (Standard) Indoline-2,3-dione (Standard)	Reference Standards Monoamine Oxidase Apoptosis	Cardiovascular Disease Neurological Disease Cancer
Isatin (Standard) is the analytical standard of Isatin. This product is intended for research and analytical applications. Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM) . Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity . Shows effect on the serotonergic system .

HY-W394903R

GS-829845 (Standard)	Reference Standards Drug Metabolite JAK	Inflammation/Immunology
Isatin (Standard) is the analytical standard of Isatin. This product is intended for research and analytical applications. Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM) . Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity . Shows effect on the serotonergic system .

HY-W029600

6,7-Dimethylisatin	Monoamine Oxidase	Neurological Disease
6,7-Dimethylisatin (compound 1l), an Isatin (HY-Y0265) analogue, is a potent MAO inhibitor with IC₅₀s of 20.3 μM and 6.74 μM for MAO-A and MAO-B, respectively. 6,7-Dimethylisatin has the potential for depression, Alzheimer's disease and Parkinson's disease research .

HY-157548

Antitumor agent-133	p62 Atg8/LC3 Autophagy	Cancer
Antitumor agent-133 (compound 4d) is a bis-isatin derivative, with activities against Huh1 (IC₅₀=17.13 μM) and Huh7 (IC₅₀=8.27 μM). Antitumor agent-133 induces cell autophagy and inhibits tumor growth through regulation of LC3BII, ATG5 and p62 proteins .

HY-162390

α-Amylase/α-Glucosidase-IN-11	Amylases Glycosidase	Endocrinology
α-Amylase/α-Glucosidase-IN-11 (Compound 5d) is a isoxazolidine-isatin hybrid with significant antidiabetic activity. α-Amylase/α-Glucosidase-IN-11 competitively inhibits α-amylase (IC₅₀ = 30.39 μM) and α-glucosidase (IC₅₀ = 65.1 μM), two key digestive enzymes. α-Amylase/α-Glucosidase-IN-11 does not cross the blood-brain barrier .

HY-169117

α-Glucosidase-IN-74	Glycosidase	Metabolic Disease
α-Glucosidase-IN-74 (Compound 7d), an isatin-thiazole derivative, is a α-glucosidase inhibitor. α-Glucosidase-IN-74 exhibits antidiabetic activity by decreasing glycaemia and triglyceride levels in Streptozotocin (HY-13753)-induced diabetic animals .

7-Methylisatin	Biochemical Assay Reagents
7-Methylisatin is a derivative of Isatin (HY-Y0265) and can be utilized as a molecular block .

*Isatin* Indoline-2,3-dione	Cardiovascular Disease Alkaloids other families Neurological Disease Classification of Application Fields Plants Disease Research Fields Indole Alkaloids Source Classification	Monoamine Oxidase Apoptosis
Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC₅₀ of 3 μM. Also binds to central benzodiazepine receptors (IC₅₀ against clonazepam, 123 μM) . Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity . Shows effect on the serotonergic system .

Isatin (Standard) Indoline-2,3-dione (Standard)	Alkaloids Structural Classification other families Plants Indole Alkaloids Source Classification	Reference Standards Monoamine Oxidase Apoptosis
Isatin (Standard) is the analytical standard of Isatin. This product is intended for research and analytical applications. Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM) . Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity . Shows effect on the serotonergic system .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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isatin-

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Natural
Products