2. Anti-infection
  3. Parasite
  4. Antileishmanial agent-13

Antileishmanial agent-13 is a quinoline-isatin hybrid, acts as an antileishmanial agent against L. Major Leishmania strain. Antileishmanial agent-13 acquires the antileishmanial activity via the anti-folate mechanism. Antileishmanial agent-13 has potent inhibition against both promastigote and amastigote forms with IC50s of 0.604 μM and 0.508 μM, respectively.

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Antileishmanial agent-13

Antileishmanial agent-13 Chemical Structure

CAS No. : 853725-86-7

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Antileishmanial agent-13 Related Antibodies

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Description

Antileishmanial agent-13 is a quinoline-isatin hybrid, acts as an antileishmanial agent against L. Major Leishmania strain. Antileishmanial agent-13 acquires the antileishmanial activity via the anti-folate mechanism. Antileishmanial agent-13 has potent inhibition against both promastigote and amastigote forms with IC50s of 0.604 μM and 0.508 μM, respectively[1].

IC50 & Target

Leishmania

 

Cellular Effect
Cell Line Type Value Description References
Vero CC50
155.8 μM
Compound: 4e
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by crystal violet staining based analysis
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by crystal violet staining based analysis
[PMID: 36493614]
In Vitro

Antileishmanial agent-13 (compound 4e) shows promising in vitro activity against the promastigote superior to Miltefosine.html" class="link-product" target="_blank">Miltefosine (HY-13685) (IC50=7.8976 µM)[1].
Antileishmanial agent-13 (2 μM; 48 h) shows antileishmanial activity mostly attributing to the anti-folate mechanism, via inhibiting DHFR-TS and PTR1[1].
Antileishmanial agent-13 (0-100 μM; 72 h) has low cytotoxicity against African green monkey kidney cells (VERO cells) with CC50 value of 155.8 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antileishmanial agent-13 Related Antibodies
Molecular Weight

401.64

Formula

C17H10BrClN4O
CAS No.
SMILES

O=C1NC2=C(/C1=N\NC3=CC=NC4=CC(Cl)=CC=C43)C=C(C=C2)Br
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antileishmanial agent-13 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antileishmanial agent-13853725-86-7Antileishmanial agent13Antileishmanial agent 13Parasitequinoline-isatin hybridL. Major LeishmaniapromastigoteamastigoteInhibitorinhibitorinhibit

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