Antileishmanial agent-13
Antileishmanial agent-13 is a quinoline-isatin hybrid, acts as an antileishmanial agent against L. Major Leishmania strain. Antileishmanial agent-13 acquires the antileishmanial activity via the anti-folate mechanism. Antileishmanial agent-13 has potent inhibition against both promastigote and amastigote forms with IC50s of 0.604 μM and 0.508 μM, respectively.
For research use only. We do not sell to patients.
- CAS No.: 853725-86-7
- Formula: C17H10BrClN4O
- Molecular Weight:401.64
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Biological Activity
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Leishmania |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero | CC50 |
155.8 μM
Compound: 4e
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Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by crystal violet staining based analysis
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by crystal violet staining based analysis
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[PMID: 36493614] |
Antileishmanial agent-13 (compound 4e) shows promising in vitro activity against the promastigote superior to Miltefosine (HY-13685) (IC50=7.8976 µM)[1].
Antileishmanial agent-13 (2 μM; 48 h) shows antileishmanial activity mostly attributing to the anti-folate mechanism, via inhibiting DHFR-TS and PTR1[1].
Antileishmanial agent-13 (0-100 μM; 72 h) has low cytotoxicity against African green monkey kidney cells (VERO cells) with CC50 value of 155.8 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 853725-86-7
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Molecular Weight 401.64
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Formula C17H10BrClN4O
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SMILES
O=C1NC2=C(/C1=N\NC3=CC=NC4=CC(Cl)=CC=C43)C=C(C=C2)Br
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antileishmanial agent-13 Related Classifications
HY-151935 Related Classifications
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