853725-86-7
853725-86-7
Chemical Structure
Antileishmanial agent-13
- CAS. Nr.: 853725-86-7
- Formula:C17H10BrClN4O
- Molecular Weight:401.64
IUPAC Name: (E)-5-bromo-3-(2-(7-chloroquinolin-4-yl)hydrazono)indolin-2-one
InChIKey: IGNUKJCOSQHXTN-UHFFFAOYSA-N
SMILES: O=C1NC2=C(/C1=N\NC3=CC=NC4=CC(Cl)=CC=C43)C=C(C=C2)Br
Biological Activity: Antileishmanial agent-13 is a quinoline-isatin hybrid, acts as an antileishmanial agent against L. Major Leishmania strain. Antileishmanial agent-13 acquires the antileishmanial activity via the anti-folate mechanism. Antileishmanial agent-13 has potent inhibition against both promastigote and amastigote forms with IC50s of 0.604 μM and 0.508 μM, respectively[1].
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Antileishmanial agent-13 | Antileishmanial agent-13 is a quinoline-isatin hybrid, acts as an antileishmanial agent against L. Major Leishmania strain. Antileishmanial agent-13 acquires the antileishmanial activity via the anti-folate mechanism. Antileishmanial agent-13 has potent inhibition against both promastigote and amastigote forms with IC50s of 0.604 μM and 0.508 μM, respectively. | |||||||||||||||||||||
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