1. Autophagy
  2. p62 Atg8/LC3 Autophagy
  3. Antitumor agent-133

Antitumor agent-133 (compound 4d) is a bis-isatin derivative, with activities against Huh1 (IC50=17.13 μM) and Huh7 (IC50=8.27 μM). Antitumor agent-133 induces cell autophagy and inhibits tumor growth through regulation of LC3BII, ATG5 and p62 proteins.

For research use only. We do not sell to patients.

Antitumor agent-133 Chemical Structure

Antitumor agent-133 Chemical Structure

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Description

Antitumor agent-133 (compound 4d) is a bis-isatin derivative, with activities against Huh1 (IC50=17.13 μM) and Huh7 (IC50=8.27 μM). Antitumor agent-133 induces cell autophagy and inhibits tumor growth through regulation of LC3BII, ATG5 and p62 proteins[1].

In Vitro

Antitumor agent-133 (0-100 μM, 48h) exhibits antitumor activities with IC50 values of 17.13 μM (Huh1) and 8.27μM (Huh7) and selectivity towards cancer cells [1].
Antitumor agent-133 (0-100 μM, 48h) induces cancer cell autophagy through regulating the expressions of LC3B (I and II), ATG5 and p62[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Antitumor agent-133 (15 mg/kg, i.p., once every two days for 14 days) inhibits tumor growth in Xenograft model in NCG mice and exhibits low toxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Huh1 xenograft model in NCG mice [1]
Dosage: i.p., 15 mg/kg, once every two days for 14 days
Administration: intraperitoneal injection
Result: Inhibited tumor growth.
Molecular Weight

692.31

Formula

C27H24Br2N4O8

SMILES

COC([C@@H](NC(CN1C(C(C2=CC(Br)=CC=C21)=O)=O)=O)CCCCNC(CN3C(C(C4=CC(Br)=CC=C43)=O)=O)=O)=O

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Antitumor agent-133 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Antitumor agent-133
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HY-157548
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