1. Neuronal Signaling
    Apoptosis
  2. Monoamine Oxidase
    Apoptosis
  3. Isatin

Isatin (Synonyms: Indoline-2,3-dione)

Cat. No.: HY-Y0265 Purity: 97.36%
Handling Instructions

Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM). Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity. Shows effect on the serotonergic system.

For research use only. We do not sell to patients.

Isatin Chemical Structure

Isatin Chemical Structure

CAS No. : 91-56-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM)[1]. Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity[2]. Shows effect on the serotonergic system[3].

IC50 & Target

IC50: 3 μM (MAO B)[1]

In Vitro

In dopaminergic SH-SY5Y cells isatin (1-400 μM) induces cell death in dose- and time dependent manner. This death occurred as a continuum of survival, apoptosis and necrosis[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

A single dose of isatin (80 mg/kg) has a rapid effect on the serotonergic system in the hypothalamus. Isatin significantly increases 5-HT concentrations in the hypothalamus and cortex but did not significantly alter 5-HIAA concentrations[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

147.13

Formula

C₈H₅NO₂

CAS No.

91-56-5

SMILES

O=C1NC2=C(C=CC=C2)C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 110 mg/mL (747.64 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.7967 mL 33.9836 mL 67.9671 mL
5 mM 1.3593 mL 6.7967 mL 13.5934 mL
10 mM 0.6797 mL 3.3984 mL 6.7967 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.75 mg/mL (18.69 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 97.36%

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Keywords:

IsatinIndoline-2,3-dioneMonoamine OxidaseApoptosisMAOInhibitorinhibitorinhibit

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