Iodine-catalyzed condensation of isatin with indoles: a facile synthesis of di(indolyl)indolin-2-ones and evaluation of their cytotoxicity

  • Bioorg Med Chem Lett. 2012 Apr 1;22(7):2460-3. doi: 10.1016/j.bmcl.2012.02.011.
B V Subba Reddy  1 ,  N Rajeswari ,  M Sarangapani ,  Y Prashanthi ,  Roopa Jones Ganji ,  Anthony Addlagatta
Affiliations
  • 1. Natural Product Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India. [email protected]
PMID: 22386528 DOI: 10.1016/j.bmcl.2012.02.011
Abstract

Isatin reacts smoothly with indoles in the presence of a catalytic amount of molecular iodine under mild conditions to afford a novel class of di(indolyl)indolin-2-one derivatives in good yields. These molecules are found to possess a promising cytotoxicity against Cancer cells only but not on normal cells.