91-56-5
91-56-5
Chemical Structure
Isatin
Synonym(s): Indoline-2,3-dione
- CAS. Nr.: 91-56-5
- Formula:C8H5NO2
- Molecular Weight:147.13
IUPAC Name: indoline-2,3-dione
InChIKey: JXDYKVIHCLTXOP-UHFFFAOYSA-N
SMILES: O=C1NC2=C(C=CC=C2)C1=O
Biological Activity: Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM)[1]. Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity[2]. Shows effect on the serotonergic system[3].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Isatin | 99.89% | Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM). Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity. Shows effect on the serotonergic system. | ||||||||||||||||||||
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Isatin (Standard) | ≥98% | Isatin (Standard) is the analytical standard of Isatin. This product is intended for research and analytical applications. Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM). Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity. Shows effect on the serotonergic system. | ||||||||||||||||||||
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Isatin-O | Isatin-O (Isatin β-oxime; Isatin 3-oxime) is an acetylcholinesterase (AChE) reactivator capable of crossing the blood-brain barrier. Isatin-O reactivates paraoxon-inhibited acetylcholinesterase in the central and peripheral nervous systems. As a glycosylation substrate, Isatin-O undergoes complete glycosylation in a Rauvolfia serpentina cell suspension culture system to form isatin-3-oxime-glucoside. Isatin-O can be used in studies related to organophosphate poisoning. | |||||||||||||||||||||
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1-Methylisatin | 99.37% | 1-Methylisatin is a potent and selective CE (carboxylesterases) inhibitor, with Kis of 38.2 and 5.38 μM for hiCE and hCE1, respectively. 1-Methylisatin interacts with Hb (human adult hemoglobin) by hydrophobic binding and electrostatic attraction. 1-Methylisatin can be used in the study of regulation of agent metabolism in vivo. | ||||||||||||||||||||
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5-Fluoroisatin | 5-Fluoroisatin is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | |||||||||||||||||||||
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7-Methylisatin | 99.14% | 7-Methylisatin is a derivative of Isatin (HY-Y0265) and can be utilized as a molecular block. | ||||||||||||||||||||
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1H-Indene-1,2(3H)-dione | 98.0% | 1H-Indene-1,2 (3H)-dione (1,2-Indandione) is a fluorescent amino acid-reactive developer used for latent fingerprint development. 1H-Indene-1,2 (3H)-dione reacts with amino acids in latent fingerprint residues to produce fluorescent products. | ||||||||||||||||||||
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3-Methylindolin-2-one | 98.89% | 3-Methylindolin-2-one is an endogenous metabolite. | ||||||||||||||||||||
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6,7-Dimethylisatin | 6,7-Dimethylisatin (compound 1l), an Isatin (HY-Y0265) analogue, is a potent MAO inhibitor with IC50s of 20.3 μM and 6.74 μM for MAO-A and MAO-B, respectively. 6,7-Dimethylisatin has the potential for depression, Alzheimer's disease and Parkinson's disease research. | |||||||||||||||||||||
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6-Hydroxyisatin | 95.86% | 6-Hydroxyisatin is an atrial natriuretic peptide receptor (ANP receptor) inhibitor. 6-Hydroxyisatin exhibits inhibitory activity against ANP-stimulated particulate guanylyl cyclase activity in rat brain cell membranes. | ||||||||||||||||||||
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5-Hydroxyisatin | 5-Hydroxyisatin can be used to synthesize anti-cancer agents. | |||||||||||||||||||||
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Oxindole (Standard) | ≥98% | Oxindole (Standard) is the analytical standard of Oxindole. This product is intended for research and analytical applications. Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors. | ||||||||||||||||||||
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References
- [1]. Glover V, et al. Isatin: Identity with the Purified Endogenous Monoamine Oxidase Inhibitor Tribulin. Journal of Neurochemistry, 51(2), 656–659.
- [2]. Igosheva N, et al. Isatin, an endogenous monoamine oxidase inhibitor, triggers a dose- and time-dependent switch from apoptosis to necrosis in human neuroblastoma cells. Neurochem Int. 2005 Aug;47(3):216-24. [Content Brief]
- [3]. McIntyre IM, et al. Serotonergic effects of isatin: an endogenous MAO inhibitor related to tribulin. J Neural Transm Gen Sect. 1990;79(1-2):35-40. [Content Brief]
