Serotonergic effects of isatin: an endogenous MAO inhibitor related to tribulin

  • J Neural Transm Gen Sect. 1990;79(1-2):35-40. doi: 10.1007/BF01250998.
I M McIntyre  1 ,  T R Norman
Affiliations
  • 1. Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia.
PMID: 1688707 DOI: 10.1007/BF01250998
Abstract

A study of the acute effects of isatin, an endogenous MAO inhibitor related to tribulin, on rat brain serotonergic function was undertaken. A single dose of isatin significantly increased 5-HT concentrations in the hypothalamus and cortex but did not significantly alter 5-HIAA concentrations. Synaptosomal 5-HT uptake was unaffected but there was a trend for the number of 3H-ketanserin binding sites was to be decreased. The results of the study are discussed in terms of the relationship of isatin to tribulin and their possible causal role in stress.

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