2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. KRAS G13D-IN-1

KRAS G13D-IN-1 (Compound 41) is a selective and covalently reversible inhibitor of KRASG13D (IC50: 0.41 nM). The selectivity for KRASG13D is 29-fold against KRAS wild type. KRAS G13D-IN-1 is an inhibitor of the GDP state and targets the SWII binding pocket of KRASG13D. KRAS G13D-IN-1 inhibits KRAS binding to GDP and turns on/off downstream signaling cascades. KRAS G13D-IN-1 can be used in the research of colon cancer.

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KRAS G13D-IN-1

KRAS G13D-IN-1 Chemical Structure

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KRAS G13D-IN-1 Related Antibodies

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Description

KRAS G13D-IN-1 (Compound 41) is a selective and covalently reversible inhibitor of KRASG13D (IC50: 0.41 nM). The selectivity for KRASG13D is 29-fold against KRAS wild type. KRAS G13D-IN-1 is an inhibitor of the GDP state and targets the SWII binding pocket of KRASG13D. KRAS G13D-IN-1 inhibits KRAS binding to GDP and turns on/off downstream signaling cascades. KRAS G13D-IN-1 can be used in the research of colon cancer[1].

IC50 & Target[1]

KRAS G13D

0.41 nM (IC50)

In Vitro

KRAS G13D-IN-1 inhibits KRASG13D (IC50: 0.41 nM). KRAS G13D-IN-1 can be used in the research of colon cancer[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KRAS G13D-IN-1 Related Antibodies
Masse moléculaire

817.32

Formule

C43H45ClF4N8O2
SMILES

NC1=N[C@@]([C@@]2=C(F)C3=C(C(N4[C@@H](C)CN(C(/C=C/C5=CC=CC6=C5C[N@@]7C[C@H]6CC7)=O)CC4)=NC(OC[C@@]89CCCN8CC(C9)=C)=N3)C=C2Cl)=C(C(F)(F)F)C(C)=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
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KRAS G13D-IN-1 Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

KRAS G13D-IN-1Rascolon cancercovalent inhibitorreversiblemolecular switchInhibitorinhibitorinhibit

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