1. Anti-infection
  2. Fungal
  3. Lanoconazole

Lanoconazole 

Cat. No.: HY-14282 Purity: 98.48%
Handling Instructions

Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo. Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis.

For research use only. We do not sell to patients.

Lanoconazole Chemical Structure

Lanoconazole Chemical Structure

CAS No. : 101530-10-3

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Based on 1 publication(s) in Google Scholar

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Description

Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo[1]. Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis[1][2].

IC50 & Target

IC50: antifungal[1]

In Vivo

Lanoconazole (treatment for ear; 0.3%-3%; 6 days) dose‐dependently suppressesTPA-induced irritant dermatitis, suppresses the production of neutrophil chemotactic factors such as keratinocyte‐derived chemokine and macrophage inflammatory protein‐2, and inhibited neutrophil infiltration to the inflammation site[2].
Lanoconazole (oral administration; 3, 10 or 30 mg/kg; once a day; 3 weeks) significantly inhibits C. neoformans compared with the saline control in normal mice. In addtion, it significantly reduces the growth of C. neoformans in the lungs and brains of MAIDS mice[3].

Animal Model: BALB/c mice[2]
Dosage: 0.3%-3% dosage
Administration: Treatment for ear
Result: Exhibited an inhibition effect of LCZ on ear swelling induced by topical application of TPA in mice.
Animal Model: Four week old C57BL/6 mice infected intraperitoneally with LP-BM5 murine leukaemia virus[3]
Dosage: 3, 10 or 30 mg/kg
Administration: Oral adminstration
Result: Inhibited C. neoformans  growth in both normal and C. neoformans -induced encephalitis MAIDS mice .
Molecular Weight

319.83

Formula

C₁₄H₁₀ClN₃S₂

CAS No.

101530-10-3

SMILES

N#C/C(N1C=CN=C1)=C2SC(C(C=CC=C3)=C3Cl)CS\2.[(E)]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

LanoconazoleFungalAntifungalimidazoledermatophytosisonychomycosisInhibitorinhibitorinhibit

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Product Name:
Lanoconazole
Cat. No.:
HY-14282
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