2. Anti-infection
  3. Fungal
  4. Lanoconazole

Lanoconazole 

Cat. No.: HY-14282 Purity: 98.00%
COA Handling Instructions

Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo. Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis.

For research use only. We do not sell to patients.

Lanoconazole Chemical Structure

Lanoconazole Chemical Structure

CAS No. : 101530-10-3

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Based on 1 publication(s) in Google Scholar

Other Forms of Lanoconazole:

Lanoconazole Related Antibodies

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Description

Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo[1]. Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis[1][2].

IC50 & Target

IC50: antifungal[1]
In Vivo

Lanoconazole (treatment for ear; 0.3%-3%; 6 days) dose‐dependently suppressesTPA-induced irritant dermatitis, suppresses the production of neutrophil chemotactic factors such as keratinocyte‐derived chemokine and macrophage inflammatory protein‐2, and inhibited neutrophil infiltration to the inflammation site[2].
Lanoconazole (oral administration; 3, 10 or 30 mg/kg; once a day; 3 weeks) significantly inhibits C. neoformans compared with the saline control in normal mice. In addtion, it significantly reduces the growth of C. neoformans in the lungs and brains of MAIDS mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice[2]
Dosage: 0.3%-3% dosage
Administration: Treatment for ear
Result: Exhibited an inhibition effect of LCZ on ear swelling induced by topical application of TPA in mice.
Animal Model: Four week old C57BL/6 mice infected intraperitoneally with LP-BM5 murine leukaemia virus[3]
Dosage: 3, 10 or 30 mg/kg
Administration: Oral adminstration
Result: Inhibited C. neoformans  growth in both normal and C. neoformans -induced encephalitis MAIDS mice .
Molecular Weight

319.83

Appearance

Solid

Formula

C14H10ClN3S2
CAS No.
SMILES

N#C/C(N1C=CN=C1)=C2SC(C(C=CC=C3)=C3Cl)CS\2.[(E)]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (312.67 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1267 mL 15.6333 mL 31.2666 mL
5 mM 0.6253 mL 3.1267 mL 6.2533 mL
10 mM 0.3127 mL 1.5633 mL 3.1267 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (7.82 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: 2.5 mg/mL (7.82 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (7.82 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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Lanoconazole Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Keywords:

Lanoconazole101530-10-3FungalAntifungalimidazoledermatophytosisonychomycosisInhibitorinhibitorinhibit

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