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  5. LP17

LP17 (LQVTDSGLYRCVIYHPP) is a BBB-penetrable triggering receptor expressed on myeloid cells (TREM-1) inhibitory peptide. LP17 substantially alleviates ischemia-induced infarction and neuronal injury. LP17 can get access into brain and block TREM-1.

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Synthèse de peptides personnalisée

LP17

LP17 Chemical Structure

CAS No. : 887255-16-5

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Based on 3 publication(s) in Google Scholar

Other Forms of LP17:

LP17 Related Antibodies

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Description

LP17 (LQVTDSGLYRCVIYHPP) is a BBB-penetrable triggering receptor expressed on myeloid cells (TREM-1) inhibitory peptide. LP17 substantially alleviates ischemia-induced infarction and neuronal injury. LP17 can get access into brain and block TREM-1[1].

IC50 & Target

TREM-1[1]
In Vitro

LP17 (1 or 10 μM; 24 h) substantially decreases mRNA levels of pro-inflammatory cytokines and chemokines after reoxygenation and remarkably attenuates extracellular protein levels of IL-1β and IL-18 in a microglia oxygen-glucose deprivation (OGD) model[1].
LP17 (10 μM; 24 h) interacts with microglial SYK[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LP17 Related Antibodies

RT-PCR[1]

Cell Line: Primary microglia
Concentration: 1 or 10 μM
Incubation Time: 24 h
Result: Decreased mRNA levels of NLRP3, IL-1β, IL-18, IL-6, CD16, CD32, iNOS, MCP-1, CXCL-1, and CXCL-2 after reoxygenation.

Western Blot Analysis[1]

Cell Line: Primary microglia
Concentration: 10 μM
Incubation Time: 24 h
Result: Suppressed ischemia/reperfusion-induced increments in CARD9, p-p65 in CARD9/NF-κB signaling and NLRP3, ASC, cleaved caspase-1, mature IL-1β, and mature IL-18 in NLRP3/caspase-1 signaling in a microglia oxygen-glucose deprivation (OGD) model.
In Vivo

LP17 (0.5 or 1 mg/kg; intranasal; daily for 3 days) alleviates ischemia-induced infarction and neuronal injury in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male C57BL/6J mice (20-25 g), mice cerebral ischemia/reperfusion (I/R) model induced by middle cerebral artery occlusion (MCAO)[1]
Dosage: 0.5 mg/kg or 1 mg/kg
Administration: Intranasal administration, once daily for 3 consecutive days after MCAO
Result: Abolished ischemia-induced TREM-1 elevation at 1 mg/kg.
Significantly reduced infarct volume by 27.3%, induced a markedly reduction in TUNEL positive cells and FJC positive neurons at 1 mg/kg.
Rescued neurological deficits and cognitive dysfunction of MCAO mice.
Inhibited microglial M1 polarization and neutrophil infiltration.
Masse moléculaire

1961.24

Formule

C89H137N23O25S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Leu-Gln-Val-Thr-Asp-Ser-Gly-Leu-Tyr-Arg-Cys-Val-Ile-Tyr-His-Pro-Pro
Sequence Shortening

LQVTDSGLYRCVIYHPP
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvant et solubilité
In Vitro: 

H2O : 35.71 mg/mL (18.21 mM; adjust pH to 3 with CH3COOH)

DMSO : 20 mg/mL (10.20 mM; ultrasonic and warming and adjust pH to 7 with CH3COOH and heat to 37°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5099 mL 2.5494 mL 5.0988 mL
5 mM 0.1020 mL 0.5099 mL 1.0198 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Calculateur de molarité

  • Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureté et documentation

Purity: 99.78%

SDS (252 KB)

COA (247 KB) LCMS (92 KB)

Instruction de manipulation (2659 KB)
Références

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 0.5099 mL 2.5494 mL 5.0988 mL 12.7470 mL
5 mM 0.1020 mL 0.5099 mL 1.0198 mL 2.5494 mL
10 mM 0.0510 mL 0.2549 mL 0.5099 mL 1.2747 mL
H2O 15 mM 0.0340 mL 0.1700 mL 0.3399 mL 0.8498 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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LP17 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LP17887255-16-5LQVTDSGLYRCVIYHPPLP 17LP-17OthersTREM-1 inhibitory peptideischemia-induced infarctionneuronal injurynervous systemInhibitorinhibitorinhibit

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