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LP17 TFA

(Synonyms: LQVTDSGLYRCVIYHPP TFA)
3 Cited Publications
Customer Review

Based on 3 publication(s) in Google Scholar

LP17 (LQVTDSGLYRCVIYHPP) TFA is a BBB-penetrable triggering receptor expressed on myeloid cells (TREM-1) inhibitory peptide. LP17 TFA substantially alleviates ischemia-induced infarction and neuronal injury. LP17 TFA can get access into brain and block TREM-1.

For research use only. We do not sell to patients.

  • Purity: 99.18%
  • Formula: C89H137N23O25S.xC2HF3O2
  • Molecular Weight:1961.24 (free base)
  • Storage:

    Sealed storage, away from moisture and light.

    Powder   -80°C, 2 years , -20°C, 1 year

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

  • LP17 TFA Chemical Structure
    LP17 TFA Chemical Structure
  • Experimental Validation Results for LP17 TFA
  • Experimental Validation Results for LP17 TFA
  • Experimental Validation Results for LP17 TFA
  • Experimental Validation Results for LP17 TFA
  • Experimental Validation Results for LP17 TFA
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Publications Citing Use of MedChemExpress (MCE) LP17 TFA

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Flow CytometryIn Vivo Efficacy StudyRT-PCRIF
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  • LP17 TFA Chemical Structure
    LP17 TFA Chemical Structure
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  • 1/16

    LP17 TFA purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 May 13:S2090-1232(25)00351-0. [Abstract]

    Customer Validation
     Representative FCM plots and summary data showing the percentage of TREM1hi MDM in mouse model with the indicated treatment (n=5). FCM analysis revealed a significant decrease in the proportion of MES-MDM following LP17 (25 mL/kg; i.v.; once every five days) treatment in the mouse model.

  • 1/16

    LP17 TFA purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 May 13:S2090-1232(25)00351-0. [Abstract]

    Customer Validation
     Survival curve of GBM-bearing mice (n = 5 mice/group). The results showed that administration of anti-PD-1 (200 µg/mouse; i.v.; once every five days) with LP17 (25 mL/kg; i.v.; once every five days) achieved combinatorial therapeutic benefits by extending animal survival.

  • 1/16

    LP17 TFA purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 May 13:S2090-1232(25)00351-0. [Abstract]

    Customer Validation
     Representative images of multiplexed immunostaining from brains of GBM-bearing mice with anti-PD-1 and/or LP17 (25 mL/kg; i.v.; once very five days) treatment.

  • 1/16

    LP17 TFA purchased from MedChemExpress. Usage Cited in: Eur J Oral Sci. 2024 Oct;132(5):e13018. [Abstract]

    Customer Validation
     The representative immunofluorescence images of M1 polarization of RAW264.7 macrophage with the treatment of LP17 (1 µg/µL; 48 h) or equal amount of PBS, indicated by DAPI, anti-CD68 and CD86 (n = 3). The results showed that blocking Trem1 with LP17 significantly reduced the mean fluorescence intensity of CD86.

  • 1/16

    LP17 TFA purchased from MedChemExpress. Usage Cited in: Eur J Oral Sci. 2024 Oct;132(5):e13018. [Abstract]

    Customer Validation
     LP17 (1 µg/µL; 48 h) downregulated the mRNA expression of M1 polarization-associated markers—TNF-α, iNOS, and CD86—in RAW264.7 macrophages by inhibiting Trem1.

  • LP17 TFA