LSD1-IN-23

Cat. No.: HY-152032: Ficha de datos Instrucciones de manejo
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LSD1-IN-23 is a competitive/non-competitive mixed inhibitor of lysine specific demethylase 1 (LSD1). LSD1-IN-23 has LSD1 inhibitory activity with an IC₅₀ value of 0.58 μM. LSD1-IN-23 can be used for the research of neuroblastoma (NB).

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LSD1-IN-23 Estructura química

No. CAS : 3033660-66-8

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Ver todos los productos específicos de isoformas Histone Demethylase:

Ver todas las isoformas

KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6 KDM7

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

IC₅₀ & Target

KDM1/LSD1

0.58 μM (IC₅₀)

In Vitro

LSD1-IN-23 (Compound 48) (0-100 μM) exhibits effective LSD1 inhibitory activity with an IC₅₀ value of 0.58 μM^[1].
LSD1-IN-23 (0.005, 0.037, 0.111, 0.333 μM; 72 h) significantly increases global H3K4Me2 in NB cells^[1].
LSD1-IN-23 (0.1 μM; 24 h) has synergistic effect combination treatment with Bortezomib in NB cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	CHP134 and IMR32 cells
Concentration:	0.1 μM
Incubation Time:	24 h
Result:	Enhanced cytotoxicity in MYCN-amplified NB cells combination treatment of bortezomib with compound 48.

Peso molecular

490.76

Fòrmula

C₁₉H₁₃BrClN₅O₂S

No. CAS

3033660-66-8

SMILES

O=S(NC(C=CC(Br)=C1)=C1C2=NNN=N2)(C3=CC=C(C=C3)C4=CC=C(C=C4)Cl)=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Catherine M Mills, et al. Synthesis and evaluation of small molecule inhibitors of LSD1 for use against MYCN-expressing neuroblastoma. Eur J Med Chem. 2022 Dec 15;244:114818. [Content Brief]

LSD1-IN-23 Related Classifications

Calculadora de molaridad
Calculadora de dilución

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LSD1-IN-233033660-66-8Histone Demethylaselysine specific demethylase 1 (LSD1)MYCNneuroblastoma (NB)anti-tumorInhibitorinhibitorinhibit

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