Lumiflavin  (Synonyms: Lumiflavine)

Lumiflavin (Lumiflavine), a riboflavine analog, causes significant inhibition of riboflavine uptake. Lumiflavin can effectively reduce the riboflavin enrichment in cancer stem-like cells (CSCs) and sensitize the effect of cisplatin Diamminedichloroplatinum (DDP) on CSCs. Lumiflavin is promising for research of ovarian cancer^[1][2][3].

Lumiflavin (10-40 μM, 48 h) has synergistic effects with Diamminedichloroplatinum (DDP) (20 μM, 48 h) on CSCs in increasing mitochondrial function damage and apoptosis rates and decreasing clonic function^[2].
Lumiflavin (0-80 μM, 72 h) reduces the formation of drug resistance and proportion of CSCs, increases CSCs/DDP apoptosis rate and reduces cell clone formation ability in ovarian cancer cell line OVCAR-3^[3].
Lumiflavin (80 μM, 72 h) downregulates the protein expression of Notch signaling pathway in CSCs/DDP^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lumiflavin (8 mg/kg, i.p., once a day for 25 days) has a synergistic cytotoxic effect on an ovarian cancer nude mice model by enhancing the DNA‐damage response and increasing the apoptotic protein expression^[2].
Lumiflavin (4-16 mg/kg, s.c., once a day for 25 days) combined with DDP reduces tumor weight and inhibits tumor growth^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

256.26

C₁₃H₁₂N₄O₂

1088-56-8

Solid

Light yellow to yellow

CC1=CC2=C(N(C(C3=N2)=NC(NC3=O)=O)C)C=C1C

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. H M Said, et al. Mechanism of riboflavine uptake by Caco-2 human intestinal epithelial cells. Am J Physiol. 1994 Jan;266(1 Pt 1):G15-21.  [Content Brief]

  [2]. Yang R, et al. Lumiflavin increases the sensitivity of ovarian cancer stem-like cells to cisplatin by interfering with riboflavin. J Cell Mol Med. 2019 Aug;23(8):5329-5339.  [Content Brief]

  [3]. Yang R, et al. Lumiflavin Reduces Cisplatin Resistance in Cancer Stem-Like Cells of OVCAR-3 Cell Line by Inducing Differentiation. Front Oncol. 2022 May 20;12:859275.  [Content Brief]