Mal-PEG3-NHS ester

Name: Mal-PEG3-NHS ester
Brand: MedChemExpress
SKU: HY-129526
Rating: 4.5 (1 reviews)

Cat. No.: HY-129526 Purity: 99.85%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Mal-PEG3-NHS ester is a noncleavable ADC linker containing a Maleimide group. Mal-PEG3-NHS ester is used for making antibody-drug conjugate.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Mal-PEG3-NHS ester 화학구조

CAS No. : 1537892-36-6

사이즈	재고	수량
100 mg	해외재고보유	Estimated Time of Arrival: December 31
250 mg	해외재고보유	Estimated Time of Arrival: December 31
1 g	해외재고보유	Estimated Time of Arrival: December 31
5 g	견적 받기
10 g	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE Mal-PEG3-NHS ester

•Nat Commun. 2026 Feb 13;17(1):2737.

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

Mal-PEG3-NHS ester is a noncleavable ADC linker containing a Maleimide group. Mal-PEG3-NHS ester is used for making antibody-drug conjugate^[1].

IC₅₀ & Target

Non-cleavable Linker

In Vitro

Maleimide-PEG-NHS ester, the heterobifunctional crosslinker, can be used to couple thiol-bearing ligands to amine-functionalized matrices^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

398.36

화학식

C₁₇H₂₂N₂O₉

CAS No.

1537892-36-6

Appearance

Liquid (Density: 1.39±0.1 g/cm³)

Color

Colorless to light yellow

SMILES

O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCN2C(C=CC2=O)=O

선적

Room temperature in continental US; may vary elsewhere.

보관

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

용액&용해도

In Vitro:

DMSO : 100 mg/mL (251.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5103 mL	12.5515 mL	25.1029 mL
5 mM	0.5021 mL	2.5103 mL	5.0206 mL
10 mM	0.2510 mL	1.2551 mL	2.5103 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.28 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.28 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

순도&문서

Purity: 99.85%

Select Batch:

Data Sheet (269 KB) SDS (393 KB)

COA (245 KB) HNMR (118 KB) RP-HPLC (237 KB) MS (154 KB)

Handling Instructions (2659 KB)

References

[1]. Gautam S, et al. Immobilization of hydrophobic peptidic ligands to hydrophilic chromatographic matrix: a preconcentration approach. Anal Biochem. 2012 Apr 15;423(2):202-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5103 mL	12.5515 mL	25.1029 mL	62.7573 mL
	5 mM	0.5021 mL	2.5103 mL	5.0206 mL	12.5515 mL
	10 mM	0.2510 mL	1.2551 mL	2.5103 mL	6.2757 mL
	15 mM	0.1674 mL	0.8368 mL	1.6735 mL	4.1838 mL
	20 mM	0.1255 mL	0.6276 mL	1.2551 mL	3.1379 mL
	25 mM	0.1004 mL	0.5021 mL	1.0041 mL	2.5103 mL
	30 mM	0.0837 mL	0.4184 mL	0.8368 mL	2.0919 mL
	40 mM	0.0628 mL	0.3138 mL	0.6276 mL	1.5689 mL
	50 mM	0.0502 mL	0.2510 mL	0.5021 mL	1.2551 mL
	60 mM	0.0418 mL	0.2092 mL	0.4184 mL	1.0460 mL
	80 mM	0.0314 mL	0.1569 mL	0.3138 mL	0.7845 mL
	100 mM	0.0251 mL	0.1255 mL	0.2510 mL	0.6276 mL