2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. Mal-VC-PAB-PNP

Mal-VC-PAB-PNP is a cleavable ADC linker. Mal-VC-PAB-PNP can be used in the synthesis of antibody-drug conjugates (ADCs).

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Mal-VC-PAB-PNP

Mal-VC-PAB-PNP 構造式

CAS 番号 : 1096584-62-1

容量 価格（税別） 在庫状況 数量
5 mg $85 在庫あり
10 mg $135 在庫あり
25 mg $270 在庫あり
50 mg $430 在庫あり
100 mg   お問い合わせ  
200 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Mal-VC-PAB-PNP 関連抗体

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ADC Linker アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

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  • 純度とドキュメンテーション

  • 参考文献

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製品説明

Mal-VC-PAB-PNP is a cleavable ADC linker. Mal-VC-PAB-PNP can be used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

Cleavable Linker

 

体外実験

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mal-VC-PAB-PNP 関連抗体
分子量

695.68

分子式

C32H37N7O11
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=[N+]([O-])C(C=C1)=CC=C1OC(OCC(C=C2)=CC=C2NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCN3C(C=CC3=O)=O)=O)=O)=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 125 mg/mL (179.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4374 mL 7.1872 mL 14.3744 mL
5 mM 0.2875 mL 1.4374 mL 2.8749 mL
10 mM 0.1437 mL 0.7187 mL 1.4374 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 99.21% ee.: 100.00%

COA (255 KB) HNMR (334 KB) NP-HPLC (133 KB) LCMS (105 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4374 mL 7.1872 mL 14.3744 mL 35.9361 mL
5 mM 0.2875 mL 1.4374 mL 2.8749 mL 7.1872 mL
10 mM 0.1437 mL 0.7187 mL 1.4374 mL 3.5936 mL
15 mM 0.0958 mL 0.4791 mL 0.9583 mL 2.3957 mL
20 mM 0.0719 mL 0.3594 mL 0.7187 mL 1.7968 mL
25 mM 0.0575 mL 0.2875 mL 0.5750 mL 1.4374 mL
30 mM 0.0479 mL 0.2396 mL 0.4791 mL 1.1979 mL
40 mM 0.0359 mL 0.1797 mL 0.3594 mL 0.8984 mL
50 mM 0.0287 mL 0.1437 mL 0.2875 mL 0.7187 mL
60 mM 0.0240 mL 0.1198 mL 0.2396 mL 0.5989 mL
80 mM 0.0180 mL 0.0898 mL 0.1797 mL 0.4492 mL
100 mM 0.0144 mL 0.0719 mL 0.1437 mL 0.3594 mL
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Mal-VC-PAB-PNP Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mal-VC-PAB-PNP1096584-62-1ADC LinkerAntibody-drug conjugates linkerADC linkercleavableInhibitorinhibitorinhibit

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製品名:
Mal-VC-PAB-PNP
製品番号:
HY-148461
数量:
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