MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH

Name: MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH
Brand: MedChemExpress
SKU: HY-131990
Rating: 4.5 (0 reviews)

Art. -Nr.: HY-131990 Reinheit: 99.32%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

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MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH Chemische Struktur

CAS. Nr. : 1599440-25-1

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50 mg	Auf Lager	Estimated Time of Arrival: December 31
100 mg	Auf Lager	Estimated Time of Arrival: December 31
250 mg	Auf Lager	Estimated Time of Arrival: December 31
1 g	Auf Lager	Estimated Time of Arrival: December 31
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Other Forms of MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH:

MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH-d₅ Angebot einholen
MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (GMP) Angebot einholen

Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Alle ADC Linker Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

Biologische Aktivität
Reinheit & Dokumentation
Verweise
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Beschreibung

MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1].

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molekulargewicht

616.62

Formel

C₂₈H₃₆N₆O₁₀

CAS. Nr.

1599440-25-1

Appearance

Solid

Color

White to off-white

SMILES

OC(COCNC(CNC([C@@H](NC(CNC(CNC(CCCCCN1C(C=CC1=O)=O)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (162.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6217 mL	8.1087 mL	16.2174 mL
5 mM	0.3243 mL	1.6217 mL	3.2435 mL
10 mM	0.1622 mL	0.8109 mL	1.6217 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 99.32%

Select Batch:

Data Sheet (267 KB) SDS (394 KB)

COA (244 KB) RP-HPLC (248 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Masuda, Takeshi, et al. Conjugué anticorps-médicament. WO2014057687A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6217 mL	8.1087 mL	16.2174 mL	40.5436 mL
	5 mM	0.3243 mL	1.6217 mL	3.2435 mL	8.1087 mL
	10 mM	0.1622 mL	0.8109 mL	1.6217 mL	4.0544 mL
	15 mM	0.1081 mL	0.5406 mL	1.0812 mL	2.7029 mL
	20 mM	0.0811 mL	0.4054 mL	0.8109 mL	2.0272 mL
	25 mM	0.0649 mL	0.3243 mL	0.6487 mL	1.6217 mL
	30 mM	0.0541 mL	0.2703 mL	0.5406 mL	1.3515 mL
	40 mM	0.0405 mL	0.2027 mL	0.4054 mL	1.0136 mL
	50 mM	0.0324 mL	0.1622 mL	0.3243 mL	0.8109 mL
	60 mM	0.0270 mL	0.1351 mL	0.2703 mL	0.6757 mL
	80 mM	0.0203 mL	0.1014 mL	0.2027 mL	0.5068 mL
	100 mM	0.0162 mL	0.0811 mL	0.1622 mL	0.4054 mL