MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH

Name: MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH
Brand: MedChemExpress
SKU: HY-131990
Rating: 4.5 (0 reviews)

Cat. No.: HY-131990 Purity: 99.32%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH 화학구조

CAS No. : 1599440-25-1

사이즈	재고	수량
무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
250 mg	해외재고보유	Estimated Time of Arrival: December 31
1 g	해외재고보유	Estimated Time of Arrival: December 31
5 g	견적 받기
10 g	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH:

MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH-d₅ 견적 받기
MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (GMP) 견적 받기

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View All Isoforms

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

Biological Activity
순도&문서
References
고객리뷰

제품 설명

MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1].

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

616.62

화학식

C₂₈H₃₆N₆O₁₀

CAS No.

1599440-25-1

Appearance

Solid

Color

White to off-white

SMILES

OC(COCNC(CNC([C@@H](NC(CNC(CNC(CCCCCN1C(C=CC1=O)=O)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

DMSO : 100 mg/mL (162.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6217 mL	8.1087 mL	16.2174 mL
5 mM	0.3243 mL	1.6217 mL	3.2435 mL
10 mM	0.1622 mL	0.8109 mL	1.6217 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.32%

Select Batch:

Data Sheet (267 KB) SDS (394 KB)

COA (244 KB) RP-HPLC (248 KB)

Handling Instructions (2659 KB)

References

[1]. Masuda, Takeshi, et al. Conjugué anticorps-médicament. WO2014057687A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6217 mL	8.1087 mL	16.2174 mL	40.5436 mL
	5 mM	0.3243 mL	1.6217 mL	3.2435 mL	8.1087 mL
	10 mM	0.1622 mL	0.8109 mL	1.6217 mL	4.0544 mL
	15 mM	0.1081 mL	0.5406 mL	1.0812 mL	2.7029 mL
	20 mM	0.0811 mL	0.4054 mL	0.8109 mL	2.0272 mL
	25 mM	0.0649 mL	0.3243 mL	0.6487 mL	1.6217 mL
	30 mM	0.0541 mL	0.2703 mL	0.5406 mL	1.3515 mL
	40 mM	0.0405 mL	0.2027 mL	0.4054 mL	1.0136 mL
	50 mM	0.0324 mL	0.1622 mL	0.3243 mL	0.8109 mL
	60 mM	0.0270 mL	0.1351 mL	0.2703 mL	0.6757 mL
	80 mM	0.0203 mL	0.1014 mL	0.2027 mL	0.5068 mL
	100 mM	0.0162 mL	0.0811 mL	0.1622 mL	0.4054 mL