2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. MC-Gly-Gly-Phe

MC-Gly-Gly-Phe is a cleavable linker used for antibody-drug conjugates (ADC).

Para uso exclusivo en investigación. No vendemos a pacientes.

MC-Gly-Gly-Phe

MC-Gly-Gly-Phe Estructura química

No. CAS : 1599440-15-9

Tamaño Precio Stock Cantidad
100 mg En stock
500 mg En stock
1 g En stock
5 g En stock
10 g En stock
25 g En stock
50 g   Obtener un presupuesto  

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Revisión del cliente

Based on 1 Customer Validation

Other Forms of MC-Gly-Gly-Phe:

MC-Gly-Gly-Phe Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas ADC Linker:

Ver todas las isoformas
Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

  • Actividad biológica

  • Pureza y Documentación

  • Referencias

  • Revisión del cliente

Descripciòn

MC-Gly-Gly-Phe is a cleavable linker used for antibody-drug conjugates (ADC).

IC50 & Target

Cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MC-Gly-Gly-Phe Related Antibodies
Peso molecular

472.49

Fòrmula

C23H28N4O7
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@H](CC1=CC=CC=C1)NC(CNC(CNC(CCCCCN2C(C=CC2=O)=O)=O)=O)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 50 mg/mL (105.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1164 mL 10.5822 mL 21.1645 mL
5 mM 0.4233 mL 2.1164 mL 4.2329 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación

Purity: 99.41%

SDS (393 KB)

COA (245 KB) HNMR (300 KB) LCMS (87 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1164 mL 10.5822 mL 21.1645 mL 52.9112 mL
5 mM 0.4233 mL 2.1164 mL 4.2329 mL 10.5822 mL
10 mM 0.2116 mL 1.0582 mL 2.1164 mL 5.2911 mL
15 mM 0.1411 mL 0.7055 mL 1.4110 mL 3.5274 mL
20 mM 0.1058 mL 0.5291 mL 1.0582 mL 2.6456 mL
25 mM 0.0847 mL 0.4233 mL 0.8466 mL 2.1164 mL
30 mM 0.0705 mL 0.3527 mL 0.7055 mL 1.7637 mL
40 mM 0.0529 mL 0.2646 mL 0.5291 mL 1.3228 mL
50 mM 0.0423 mL 0.2116 mL 0.4233 mL 1.0582 mL
60 mM 0.0353 mL 0.1764 mL 0.3527 mL 0.8819 mL
80 mM 0.0265 mL 0.1323 mL 0.2646 mL 0.6614 mL
100 mM 0.0212 mL 0.1058 mL 0.2116 mL 0.5291 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

MC-Gly-Gly-Phe Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MC-Gly-Gly-Phe1599440-15-9ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

Productos vistos recientemente:

Consulta en línea

Your information is safe with us. * Required Fields.

Nombre del producto

  

Requested Quantity *

Nombre del solicitante *

 

Saludo

Direcciòn del E-mail *

 

Número de teléfono *

Department

 

Nombre de la Organizaciòn *

City

Provincia

Country or Region *

      

Observaciones

Consulta para venta a granel

Inquiry Information

Nombre del producto:
MC-Gly-Gly-Phe
Cat. No.:
HY-44235
Cantidad:
MCE Japan Authorized Agent:

Revisión del cliente

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Nombre del producto

  

Lot #

Nombre del solicitante *

 

Direcciòn del E-mail *

Número de teléfono

 

Department *

Nombre de la Organizaciòn *

 

Country or Region *

Observaciones

SAFETY DATA SHEET (SDS)

English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB) Italian - IT (393 KB) Korean - KR (393 KB) Portuguese - PT (393 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.