2. Peptides

Peptides

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Peptides, which are short chains of amino acids linked by peptide bonds, have a variety of biological functions, such as, anti-thrombosis, anti-hypertension, anti-microbial, anti-tumor and anti-oxidation, immune-regulation, and cholesterol-lowering effects. Peptides have been widely used in functional analysis, antibody research, vaccine research, and especially the field of drug research and development.

MedChemExpress (MCE) offers a comprehensive collection of high quality peptides including peptide inhibitors, β-amyloids, therapeutic peptides and amino acid derivatives to clients in pharmaceutical and academic institutions all over the world. Unlimited Custom Peptide Service is also available to help researchers propel their projects.

Peptides

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Peptides (9459):

Cat. No. 상품명 CAS No. Purity 화학구조
  • HY-P10816
    PACE4 Inhibitory peptide C23 1426656-94-1 99.40%
    PACE4 Inhibitory peptide C23 (Compound C23; Ac-(DLeu)LLLRVK-Amba)), a potent peptidomimetic inhibitor, is a PACE4 inhibitor. PACE4 Inhibitory peptide C23e shows antiproliferative effects against PCa cell lines (Ki = 5 nM; IC50 = 25 and 40 μM for DU145 and LNCaP, respectively). PACE4 Inhibitory peptide C23 also blocks tumor growth in vivo in LNCaP xenograft-bearing mice.
    PACE4 Inhibitory peptide C23
  • HY-P10839
    NBD peptide 371915-62-7 98.02%
    NBD peptide inhibits NF-κB signaling pathway through inhibition of the NEMO-IKK complex combination. NBD peptide exhibits anti-inflammatory efficacy through block of pro-inflammatory cytokines production. NBD peptide exhibits immunosuppressive activity through regulation of immune cells. NBD peptide enhances its transmembrane ability by combining with cell-penetrating peptide HIV-TAT.
    NBD peptide
  • HY-P10862
    AH-D peptide 99.32%
    AH-D peptide is a brain-penetrant antiviral agent disrupting highly curved lipid membranes. AH-D peptide exhibits broad-spectrum antiviral activity against ZIKV, Dengue virus, Chikungunya virus, yellow fever virus and Japanese encephalitis virus, with
    IC50
    values of 11.9, 12.5, 35.7, 206 and 136 nM, respectively. AH-D peptide reduces the viral load in the brain, suppresses inflammation, protects neurons, and does not damage the blood brain barrier. AH-D peptide restores antitumor immunity by decreasing circulating PD-L1+ exosomes, reducing intratumoral immunosuppressive cells (regulatory T cells, myeloid-derived suppressor cells), and enhancing T cell function. AH-D peptide inhibits membrane-enveloped viruses and cancer cell metastasis in vivo. AH-D peptide exhibits no immunogenicity and has negligible effects on normal tissues. AH-D peptide can be used for research in Zika virus and other mosquito-borne viruses, cancer immunotherapy and metastasis.
    AH-D peptide
  • HY-P10895
    HR97 TFA 99.00%
    HR97 TFA is a cell-penetrating peptide that can be combined with engineered melanin to prepare eye drops HR97-SunitiGel. The peptide-drug conjugate in HR97-SunitiGel can provide sustained ocular drug delivery.
    HR97 TFA
  • HY-P10913
    HYNIC-UBI29-41 1186217-15-1 98.34%
    HYNIC-UBI29-41 is composed of a bifunctional chelator HYNIC and an antimicrobial peptide UBI 29-41 (HY-P10364) (HY-P10364). HYNIC-UBI29-41 retains the antibacterial properties of UBI 29-41, and exhibits good affinity to Gram-positive and Gram-negative bacteria. HYNIC-UBI29-41 can be used as an imaging agent for bacterial infection detection in mouse models, when labeled with the radioactive element technetium (99mTc).
    HYNIC-UBI29-41
  • HY-P10934
    LXY3 1095009-44-1 98.33%
    LXY3 (LXY2) is a VLA-3-blocking peptide that inhibits the interaction between integrin α3β1 (VLA-3) on neutrophil surfaces and laminin in the basement membrane, thereby preventing neutrophil migration across the tumor vascular basement membrane barrier. LXY3 is used to block neutrophil-mediated nanoparticle release from perivascular pools into the tumor interstitium. LXY3 is commonly employed for targeted imaging of breast cancer.
    LXY3
  • HY-P10940
    Ac-RFAAKAA-COOH 845727-63-1 99.54%
    Ac-RFAAKAA-COOH is a cysteine-containing polypeptide with a reactive lysine residue, and serves as a substrate for covalent modification and chemical reactivity assays. Ac-RFAAKAA-COOH forms stable covalent adducts with isothiocyanates, resulting in peptide depletion over time. Ac-RFAAKAA-COOH acts as a model peptide in direct peptide reactivity assays, where its chemical reactivity is evaluated via fluorescamine-based free amine assays. Ac-RFAAKAA-COOH can be used in studies related to allergic contact dermatitis and skin sensitization.
    Ac-RFAAKAA-COOH
  • HY-P10943
    APO-15 3051946-11-0 99.45%
    APO-15 is a phosphatidylserine-binding fluorescent probe and apoptosis imaging reagent. APO-15 exhibits high chemical stability under proteolytic and oxidative conditions, enables quantification and imaging of drug-induced apoptosis in preclinical mouse models, and is applicable to fixed tissue samples and multiple in vivo administration routes (Ex = 488 nm; Em = 525 nm). APO-15 can be used in studies related to acute lung injury and breast cancer.
    APO-15
  • HY-P11056
    REF1 peptide 1198397-79-3 99.95%
    REF1 peptide is a PORK1 agonist with an EC50 of 0.028 nM in tomato. REF1 peptide binds to the extracellular domain of PORK1, triggers receptor autophosphorylation, and drives downstream MPK3/MPK6 activation, thereby initiating defense and regeneration signaling cascades. REF1 peptide induces callus formation, inhibits shoot regeneration upon continuous exposure, and enhances the regeneration and transformation efficiency of recalcitrant dicotyledonous and monocotyledonous crops.
    REF1 peptide
  • HY-P11070
    SDSSD 1927877-75-5 99.60%
    SDSSD is an osteoblast-targeting peptide. SDSSD selectively binds to periostin on osteoblasts and mediates targeted delivery to these cells. SDSSD can endow calcium phosphate nanocomposites with bone-targeting properties, and these materials exhibit osteointegrative capacity in both in vitro and in vivo models. When conjugated with polyurethane nanomicelles, SDSSD enables targeted delivery of siRNA/microRNA to osteoblasts.
    SDSSD
  • HY-P11175
    Competence-stimulating peptide 438620-89-4 99.38%
    Competence-stimulating peptide is a competence-stimulating peptide. Competence-stimulating peptide activates the Com-dependent quorum sensing system of S. mutans. Competence-stimulating peptide restores bacteriocin production.
    Competence-stimulating peptide
  • HY-P11213
    Ac-RYQK(Ac)-AMC 99.55%
    Ac-RYQK(Ac)-AMC (Compound S5) is a fluorescent substrate for SITR6, that is based on the H3 sequence. Ac-RYQK(Ac)-AMC mimics H3K56 deacetylation site and significantly increases the deacetylation signal with superior signal-to-background ratio. Ac-RYQK(Ac)-AMC can be used for ageing and cancers research.
    Ac-RYQK(Ac)-AMC
  • HY-P11308
    Cys-GE11 1421680-54-7 98.03%
    Cys-GE11 is an N-terminal modified GE11 (HY-P10128) with cysteine ​​(Cys) added. Cys-GE11 can be coupled through the thiol group of Cys. Cys-GE11 can be linked to PEG-P (TMC-DTC) through the N-terminus of cysteine to form a targeted polymer. Cys-GE11 can target cells with high EGFR expression (such as SMMC-7721 cells). Cys-GE11 can significantly enhance drug enrichment at the tumor site and exhibit low toxicity.
    Cys-GE11
  • HY-P11320
    Davalintide 863919-85-1 98.04%
    Davalintide is an Amylin (HY-P1464)-mimetic peptide with greater potency and longer-lasting effects. Davalintide is a potent agonist of amylin receptor (IC50 = 0.04 nM), calcitonin receptor (IC50 = 0.06 nM) and calcitonin related peptide receptor (CGRP receptor) (IC50 = 3.1 nM). Davalintide shows stronger potency to Amylin to activate cyclic AMP production through the calcitonin receptor (EC50 = 1.4 nM). Davalintide regulates blood sugar and weight through various mechanisms such as delaying gastric emptying, inhibiting glucagon secretion, and reducing food intake. Davalintide can be used for the studies of anti-obesity and anti-diabetes.
    Davalintide
  • HY-P11541
    CTP-Cys 2300065-35-2
    CTP-Cys is a cysteine attached to CTP (HY-P4094) for peptide conjugation.
    CTP-Cys
  • HY-P1209A
    PG106 TFA 98.42%
    PG106 TFA is a potent and selective human melanocortin 3 (hMC3) receptor antagonist (IC50= 210 nM) and has noactivity at hMC4 receptors (EC50=9900 nM) and hMC5 receptor.
    PG106 TFA
  • HY-P1346A
    APETx2 TFA 99.57%
    APETx2 TFA, a sea anemone peptide from Anthopleura elegantissima, is a selective and reversible ASIC3 inhibitor, with an IC50 of 63 nM. APETx2 directly inhibits the ASIC3 channel by acting at its external side. APETx2 could reverses acid‐induced and inflammatory pain.
    APETx2 TFA
  • HY-P1377A
    Caffeic acid-pYEEIE TFA 98.47%
    Caffeic acid-pYEEIE TFA, a phosphopeptide inhibitor, exhibits potent binding affinity for the GST-Lck-SH2 domain.
    Caffeic acid-pYEEIE TFA
  • HY-P1382A
    Rac1 Inhibitor W56 TFA 99.92%
    Rac1 Inhibitor W56 TFA is a peptide containing residues 45-60 of Rac1. Rac1 Inhibitor W56 TFA inhibits Rac1 interaction with guanine nucleotide exchange factors TrioN, GEF-H1, and Tiam.
    Rac1 Inhibitor W56 TFA
  • HY-P1452A
    RNAIII-inhibiting peptideTFA 2703745-76-8 99.66%
    RNAIII-inhibiting peptide(TFA) is a potent inhibitor of Staphylococcus aureus, effective in the diseases such as cellulitis, keratitis, septic arthritis, osteomylitis and mastitis.
    RNAIII-inhibiting peptideTFA