2. Cytoskeleton
  3. Integrin
  4. LXY3

LXY3 (LXY2) is a VLA-3-blocking peptide that inhibits the interaction between integrin α3β1 (VLA-3) on neutrophil surfaces and laminin in the basement membrane, thereby preventing neutrophil migration across the tumor vascular basement membrane barrier. LXY3 is used to block neutrophil-mediated nanoparticle release from perivascular pools into the tumor interstitium. LXY3 is commonly employed for targeted imaging of breast cancer.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

LXY3

LXY3 Chemical Structure

CAS No. : 1095009-44-1

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Based on 1 publication(s) in Google Scholar

LXY3 Related Antibodies

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

LXY3 (LXY2) is a VLA-3-blocking peptide that inhibits the interaction between integrin α3β1 (VLA-3) on neutrophil surfaces and laminin in the basement membrane, thereby preventing neutrophil migration across the tumor vascular basement membrane barrier. LXY3 is used to block neutrophil-mediated nanoparticle release from perivascular pools into the tumor interstitium. LXY3 is commonly employed for targeted imaging of breast cancer[1][2].

Cellular Effect
Cell Line Type Value Description References
MDA-MB-231 IC50
7.4 μM
Compound: 1, LXY3, cdGTyr(3-NO2)GHypNc
Binding affinity to alpha3beta1 integrin receptor in human MDA-MB-231 cells assessed as inhibition of cell binding to immobilized LXY1 peptide by cell adherence assay
Binding affinity to alpha3beta1 integrin receptor in human MDA-MB-231 cells assessed as inhibition of cell binding to immobilized LXY1 peptide by cell adherence assay
[PMID: 19835381]
Molecular Weight

885.88

Formula

C32H43N11O15S2
CAS No.
Appearance

Solid

Color

White to light yellow

Sequence

{d-Cys}-{d-Asp}-Gly-{Tyr(3-NO2)}-Gly-{Hyp}-Asn-{d-Cys}-NH2 (disulfide bridge: d-Cys1-d-Cys8)
Sequence Shortening

{d-Cys}-{d-Asp}-G-{Tyr(3-NO2)}-G-{Hyp}-N-{d-Cys}-NH2 (disulfide bridge: d-Cys1-d-Cys8)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (112.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1288 mL 5.6441 mL 11.2882 mL
5 mM 0.2258 mL 1.1288 mL 2.2576 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1288 mL 5.6441 mL 11.2882 mL 28.2205 mL
5 mM 0.2258 mL 1.1288 mL 2.2576 mL 5.6441 mL
10 mM 0.1129 mL 0.5644 mL 1.1288 mL 2.8221 mL
15 mM 0.0753 mL 0.3763 mL 0.7525 mL 1.8814 mL
20 mM 0.0564 mL 0.2822 mL 0.5644 mL 1.4110 mL
25 mM 0.0452 mL 0.2258 mL 0.4515 mL 1.1288 mL
30 mM 0.0376 mL 0.1881 mL 0.3763 mL 0.9407 mL
40 mM 0.0282 mL 0.1411 mL 0.2822 mL 0.7055 mL
50 mM 0.0226 mL 0.1129 mL 0.2258 mL 0.5644 mL
60 mM 0.0188 mL 0.0941 mL 0.1881 mL 0.4703 mL
80 mM 0.0141 mL 0.0706 mL 0.1411 mL 0.3528 mL
100 mM 0.0113 mL 0.0564 mL 0.1129 mL 0.2822 mL
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LXY3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LXY31095009-44-1LXY2LXY 3LXY-3LXY 2LXY-2IntegrinMDA-MB-231breast cancerInhibitorinhibitorinhibit

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