2. Academic Validation
  3. A dermatan sulfate-functionalized biomimetic nanocarrier for melanoma targeted chemotherapy

A dermatan sulfate-functionalized biomimetic nanocarrier for melanoma targeted chemotherapy

  • Carbohydr Polym. 2020 May 1;235:115983. doi: 10.1016/j.carbpol.2020.115983.
Shanshan Li 1,  Fuzhong Zhang 2,  Yang Yu 1,  Qixiong Zhang 3
Affiliations

Affiliations

  • 1 Department of Pharmaceutical Engineering, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
  • 2 Chengdu Institute of Chinese Herbal Medicine, Chengdu 610000, China.
  • 3 Department of Pharmaceutics, Army Medical University, Chongqing 400038, China. Electronic address: [email protected].
PMID: 32122513 DOI: 10.1016/j.carbpol.2020.115983
Abstract

Melanoma is a malignant tumor of melanocytes that is a serious threat to human health. Dermatan sulfate (DS) is a natural glycosaminoglycan. Inspired by the origin of DS, we report a DS-functionalized biomimetic chitosan nanocarrier (DCNP) for melanoma targeted chemotherapy. DS can anchor to the surface of the chitosan nanocarrier (CNP) by forming amide bond. The SN38/DCNP can rapidly release the anti-tumor drug under acidic conditions. The functionalization of DS not only promoted the specific uptake behavior of melanoma cells, but also up-regulated cleaved Caspase-3 and PARP promote tumor cell Apoptosis. In vivo model, DCNP reduced the non-specific distribution of SN38 in the circulation and other tissues, while shows superior tumor targeting ability. SN38/DCNP significantly inhibit tumor growth and improved the survival rate. Moreover, SN38/DCNP has a milder myelosuppressive effect. The above results indicated that DS could be used as an excellent targeting unit for the treatment of melanoma.

Keywords

Biomimetic; Dermatan sulfate; Melanoma; Targeted therapy.

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